Anti-CD40 Ligand Antibody

Cat: 10239-R202
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All CD40 Ligand Reagents
Anti-CD40 Ligand Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD40 Ligand Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD40 Ligand
Immunogen
Recombinant Human CD40L / CD154 / TNFSF5 protein (Catalog#10239-H08E)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD40L / CD154 / TNFSF5 (rh CD40L / CD154 / TNFSF5; Catalog#10239-H08E; NP_000065.1; Glu 108-Leu 261).
Source
Monoclonal Rabbit IgG Clone #202
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD40 Ligand Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD40 Ligand Antibody Alternative Names
Anti-CD154 Antibody;Anti-CD40 Ligand Antibody;Anti-CD40L Antibody;Anti-gp39 Antibody;Anti-hCD40L Antibody;Anti-HIGM1 Antibody;Anti-IGM Antibody;Anti-IMD3 Antibody;Anti-T-BAM Antibody;Anti-TNFSF5 Antibody;Anti-TRAP Antibody
CD40 Ligand Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD154, also known as CD40 ligand or CD40L, is a member of the TNF superfamily. While CD154 was originally found on T cell surface, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages and NK cells. CD154's ability is achieved through binding to the CD40 on antigen- presenting cells (APC). In the macrophage cells, the primary signal for activation is IFN-γ from Th1 type CD4 T cells. The secondary signal is CD40L on the T cell, which interacting with the CD40 molecules, helping increase the level of activation.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD40 ligand
Research Areas
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Grewal IS, et al. (1998) CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology. 16: 111-35.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD40 Ligand Antibody Rabbit Polyclonal ELISA 10239-RP01
    Anti-CD40 Ligand Antibody Mouse Monoclonal ELISA 10239-MM04
    Anti-CD40 Ligand Antibody Rabbit Monoclonal ELISA 10239-R301
    Anti-CD40 Ligand Antibody Rabbit Polyclonal WB,ELISA 10239-T48
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