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CD40/TNFRSF5 Protein, Antibody, ELISA Kit, cDNA Clone

Cynomolgus CD40/TNFRSF5 Protein

Expression host: Human Cells
  • Slide 1
90097-C02H-50
90097-C02H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
90097-C08H-50
90097-C08H-100
50 µg / $178
100 µg / $298
Add to Cart

Rat CD40/TNFRSF5 Protein

Expression host: Human Cells
  • Slide 1
80151-R02H-50
80151-R02H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
80151-R08H-50
80151-R08H-100
50 µg / $178
100 µg / $298
Add to Cart

Canine CD40/TNFRSF5 Protein

Expression host: Human Cells
  • Slide 1
70105-D02H-50
70105-D02H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
70105-DCCH-50
70105-DCCH-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
70105-D08H-50
70105-D08H-100
50 µg / $178
100 µg / $298
Add to Cart

Mouse CD40/TNFRSF5 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
50324-M03H-50
50324-M03H-100
50 µg / $178
100 µg / $298
Add to Cart

Human CD40/TNFRSF5 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
10774-H03H-50
10774-H03H-100
50 µg / $178
100 µg / $298
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
10774-H08H-50
10774-H08H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
  • Slide 1
10774-H02H-100
10774-H02H-50
100 µg / $298
50 µg / $178
Add to Cart

CD40/TNFRSF5 Related Areas

CD40/TNFRSF5 Related Pathways

CD40/TNFRSF5 Related Product

CD40/TNFRSF5 Summary & Protein Information

CD40/TNFRSF5 Related Information

CD40/TNFRSF5 Background

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
General information above from NCBI
Subunit structure: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.
Subcellular location: Isoform I: Cell membrane; Single-pass type I membrane protein.
Isoform II: Secreted.
Tissue specificity: B-cells and in primary carcinomas.
Involvement in disease: Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 4 TNFR-Cys repeats.
General information above from UniProt

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

CD40/TNFRSF5 Alternative Name

Bp50,CD40,CDW40,MGC9013,p50,TNFRSF5, [human]
p50,gp39,HIGM1,IGM,IMD3,T-BAM,TRAP,AI326936,Bp50,Cd40,RP23-428M13.1,Tnfrsf5, [mouse]

CD40/TNFRSF5 Related Studies

  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
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