Anti-CD40 Antibody (FITC)

Cat: 10774-MM03-F
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Anti-CD40 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-CD40 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CD40
Immunogen
Recombinant Human CD40 protein (Catalog#10774-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD40 / TNFRSF5 (rh CD40 / TNFRSF5; Catalog#10774-H08H; NP_001241.1; Met 1-Arg 193) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG2b Clone #3A4B7
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD40 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD40 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human CD40/TNFRSF5 Flow Cytometry (FC) 2548
Profile of CD40 reactivity on Daudi cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with 10 μg of human IgG/106 cells for 1 hour at 4℃ prior to staining, washed, then stained with FITC Mouse anti-CD40 (MM03).
Anti-CD40 Antibody (FITC) Alternative Names
Anti-Bp50 Antibody;Anti-CDW40 Antibody;Anti-p50 Antibody;Anti-TNFRSF5 Antibody
CD40 Background Information

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD40 molecule, TNF receptor superfamily member 5
References
  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 90097-T16
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 90097-RP01
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 80151-RP01
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 80151-T16
    Anti-CD40 Antibody (PE) Mouse Monoclonal FCM 80151-MM01-P
    Anti-CD40 Antibody Mouse Monoclonal ELISA 80151-MM11
    Anti-CD40 Antibody (APC) Mouse Monoclonal FCM 80151-MM01-A
    Anti-CD40 Antibody Mouse Monoclonal FCM 80151-MM01
    Anti-CD40 Antibody (FITC) Mouse Monoclonal FCM 80151-MM01-F
    Anti-CD40 Antibody Rabbit Polyclonal IHC-P,ICC/IF,IF 102296-T10
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 10774-RP01
    Anti-CD40 Antibody Mouse Monoclonal ELISA(Cap) 10774-MM11
    Anti-CD40 Antibody Mouse Monoclonal ELISA 10774-MM05
    Anti-CD40 Antibody (APC) Mouse Monoclonal FCM 10774-MM03-A
    Anti-CD40 Antibody Rabbit Polyclonal WB,ELISA 10774-RP02
    Anti-CD40 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10774-R004
    Anti-CD40 Antibody (PE) Mouse Monoclonal FCM 10774-MM17-P
    Anti-CD40 Antibody (APC) Mouse Monoclonal FCM 10774-MM17-A
    Anti-CD40 Antibody (FITC) Mouse Monoclonal FCM 10774-MM17-F
    Anti-CD40 Antibody Rabbit Polyclonal ELISA,IHC-P 10774-T24
    Anti-CD40 Antibody Mouse Monoclonal FCM,ICC/IF,IF 10774-MM17
    Anti-CD40 Antibody Mouse Monoclonal FCM,ICC/IF,IF 10774-MM03
    Anti-CD40 Antibody Rabbit Polyclonal WB,IP 101510-T36
    Anti-CD40 Antibody Rabbit Polyclonal WB 101510-T32
    Anti-CD40 Antibody (PE) Mouse Monoclonal FCM 10774-MM03-P
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 10774-T16
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