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CD40 / TNFRSF5 Antibody (FITC), Mouse MAb

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Human CD40 Antibody Product Information
Immunogen:Recombinant Human CD40 protein (Catalog#10774-H08H)
Clone ID:3A4B7
Ig Type:Mouse IgG2b
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD40 / TNFRSF5 (rh CD40 / TNFRSF5; Catalog#10774-H08H; NP_001241.1; Met 1-Arg 193) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human CD40 Antibody Usage Guide
Specificity:Human CD40 / TNFRSF5
No cross-reactivity in ELISA with
Human CD27
Mouse CD27
Human CD30
Human DR6
Human 4-1BB
Human HVEM
Mouse HVEM
Human RELT
Human cell lysate (293 cell line)
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human CD40 Antibody FC Application Image
[Click to enlarge image]
Profile of CD40 reactivity on Daudi cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with 10 μg of human IgG/106 cells for 1 hour at 4℃ prior to staining, washed, then stained with FITC Mouse anti-CD40 (MM03).
CD40 / TNFRSF5 Antibody (FITC), Mouse MAb, Flow cytometric
Other CD40 Antibody Products
CD40/TNFRSF5 Background

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Human CD40/TNFRSF5 References
  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
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    Catalog: 10774-MM03-F-50
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