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CD40 / TNFRSF5 / Bp50 Antibody, Rabbit MAb

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    Human CD40 Antibody Product Information
    Immunogen:Recombinant Human CD40 protein (Catalog#10774-H08H)
    Clone ID:4
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD40 extracellular domain (rh CD40; Catalog#10774-H08H; NP_001241.1; Met 1-Arg 193).
    Other CD40 Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10774-MM03-A-50
    10774-MM03-A-100
    50 Tests 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10774-MM03-P-50
    10774-MM03-P-100
    50 Tests 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  IF  ICC/IF  
    • Slide 1
    • Slide 1
    10774-MM17-200
    10774-MM17-100
    10774-MM17-50
    200 µg 
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  IF  ICC/IF  
    • Slide 1
    • Slide 1
    10774-MM03-100
    10774-MM03-50
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10774-RP01-400
      10774-RP01-100
      10774-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  
      • Slide 1
      10774-RP02-200
      10774-RP02-50
      10774-RP02-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10774-MM05-200
        10774-MM05-50
        10774-MM05-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10774-MM03-F-50
        10774-MM03-F-100
        50 Tests 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10774-MM17-A-100
        10774-MM17-A-50
        100 Tests 
        50 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10774-MM17-F-100
        10774-MM17-F-50
        100 Tests 
        50 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10774-MM17-P-100
        10774-MM17-P-50
        100 Tests 
        50 Tests 
        Add to Cart
        Reactivity: Human  
        Application: WB  IP  
        • Slide 1
        • Slide 1
        101510-T36-100
        101510-T36-50
        101510-T36-200
        100 µg 
        50 µg 
        200 µg 
        Add to Cart
        Reactivity: Rat  
        Application: ELISA  
          80151-RP01-400
          80151-RP01-200
          80151-RP01-100
           
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Rat  
          Application: FCM  
          • Slide 1
          80151-MM01-200
          80151-MM01-100
          80151-MM01-50
          200 µg 
          100 µg 
          50 µg 
          Add to Cart
          Reactivity: Rat  
          Application: FCM  
          • Slide 1
          80151-MM01-F-50
          80151-MM01-F-100
          50 Tests 
          100 Tests 
          Add to Cart
          Reactivity: Rat  
          Application: FCM  
          • Slide 1
          80151-MM01-P-100
          80151-MM01-P-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  
            80151-T16-200
            80151-T16-50
            80151-T16-100
            200 µg 
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Cynomolgus  
            Application: ELISA  
              90097-T16-200
              90097-T16-50
              90097-T16-100
              200 µg 
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Rhesus  
              Application: ELISA  
                90097-RP01-400
                90097-RP01-200
                90097-RP01-100
                 
                200 µg 
                100 µg 
                Add to Cart
                Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
                CD40/TNFRSF5 Background

                CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

                Immune Checkpoint
                Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
                Immune Checkpoint Proteins
                Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

                Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                Human CD40/TNFRSF5 References
              • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
              • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
              • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
              • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
              • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
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                Size / Price
                Catalog: 10774-R004-1
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"