Anti-CD40 Antibody

Cat: 10774-MM05
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All CD40 Reagents
Anti-CD40 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD40 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human CD40
No cross-reactivity in ELISA with Human CD27 / TNFRSF7 Mouse CD27 / TNFRSF7 Human CD30 / TNFRSF8 Human DR6 / TNFRSF21 Human CD137 / 4-1BB Human TNFRSF1B / CD120b Human HVEM / TNFRSF14 Mouse HVEM / TNFRSF14 Human RELT / TNFRSF19L Human cell lysate (293 cell line)
Recombinant Human CD40 protein (Catalog#10774-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD40 extracellular domain (rh CD40; Catalog#10774-H08H; NP_001241.1; Met 1-Arg 193). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2b Clone #2B11B7
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD40 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD40 Antibody Alternative Names
Anti-Bp50 Antibody;Anti-CDW40 Antibody;Anti-p50 Antibody;Anti-TNFRSF5 Antibody
CD40 Background Information

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD40 molecule, TNF receptor superfamily member 5
  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 90097-T16
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 90097-RP01
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 80151-RP01
    Anti-CD40 Antibody (PE) Mouse Monoclonal FCM 80151-MM01-P
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 80151-T16
    Anti-CD40 Antibody Mouse Monoclonal ELISA 80151-MM11
    Anti-CD40 Antibody (APC) Mouse Monoclonal FCM 80151-MM01-A
    Anti-CD40 Antibody Mouse Monoclonal FCM 80151-MM01
    Anti-CD40 Antibody (FITC) Mouse Monoclonal FCM 80151-MM01-F
    Anti-CD40 Antibody Rabbit Polyclonal IHC-P,ICC/IF,IF 102296-T10
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 10774-RP01
    Anti-CD40 Antibody Mouse Monoclonal ELISA(Cap) 10774-MM11
    Anti-CD40 Antibody (APC) Mouse Monoclonal FCM 10774-MM03-A
    Anti-CD40 Antibody Rabbit Polyclonal ELISA,IHC-P 10774-T24
    Anti-CD40 Antibody (FITC) Mouse Monoclonal FCM 10774-MM17-F
    Anti-CD40 Antibody Rabbit Polyclonal ELISA 10774-T16
    Anti-CD40 Antibody Mouse Monoclonal FCM,ICC/IF,IF 10774-MM17
    Anti-CD40 Antibody Mouse Monoclonal FCM,ICC/IF,IF 10774-MM03
    Anti-CD40 Antibody (PE) Mouse Monoclonal FCM 10774-MM03-P
    Anti-CD40 Antibody Rabbit Polyclonal WB 101510-T32
    Anti-CD40 Antibody Rabbit Polyclonal WB,ELISA 10774-RP02
    Anti-CD40 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10774-R004
    Anti-CD40 Antibody (PE) Mouse Monoclonal FCM 10774-MM17-P
    Anti-CD40 Antibody (APC) Mouse Monoclonal FCM 10774-MM17-A
    Anti-CD40 Antibody (FITC) Mouse Monoclonal FCM 10774-MM03-F
    Anti-CD40 Antibody Rabbit Polyclonal WB,IP 101510-T36
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