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CD4 Protein & Antibody (L3T4)

Cluster of Differentiation 4

CD4 Products

CD4 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No Price / Size
CD4 Human CD4/Fc Protein, Recombinant 10400-H03H $290 / 100µg
CD4 Human CD4 Protein, Recombinant 10400-H08H $290 / 100µg
CD4 Human CD4 (aa 1-208) Protein, Recombinant 10400-H08H1 $290 / 100µg
CD4 Mouse CD4 Protein, Recombinant 50134-M08H $290 / 100µg
CD4 Ferret CD4 Protein, Recombinant 60003-F08H $290 / 50µg

CD4 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat No Price / Size
Human CD4 WB, ELISA CD4 Antibody, Rabbit Mab 10400-R104 $290 / 100µg
Human CD4 WB FCM CD4 Antibody ( FITC ) 10400-R005-F $200 / 100 Tests
Human CD4 ELISA CD4 / LEU3 Antibody 10400-MM03 $200 / 100µg
Human CD4 WB CD4 / LEU3 Antibody 10400-MM04 $200 / 100µg
Human CD4 WB, ELISA CD4 Antibody 10400-RP01 $190 / 200µg
Human CD4 WB, ELISA CD4 Antibody (Antigen Affinity Purified) 10400-RP02 $290 / 100µg
Mouse CD4 WB, ELISA CD4 Antibody, Rabbit MAb 50134-R001 $290 / 100µg

Mouse CD4

WB, ELISA Rabbit Polyclonal Antibody 50134-RP01 $190 / 200µg
Mouse CD4 WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 50134-RP02 $290 / 100µg
Ferret CD4 WB, ELISA CD4 Antibody 60003-MM09 $200 / 100µg
Ferret CD4 WB, ELISA CD4 Antibody (Antigen Affinity Purified) 60003-RP02 $290 / 100µg

CD4 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No Price / Size
CD4 Human Human CD4 cDNA Clone / ORF Clone HG10400-M $95
CD4 Mouse Mouse CD4 cDNA Clone / ORF Clone MG50134-M $95
CD4 Ferret Ferret CD4 cDNA Clone / ORF Clone FG60006-G $95
CD4 Rat Rat CD4 cDNA Clone / ORF Clone RG80086-G $125
CD4 Cynomolgus Cynomolgus monkey CD4 Gene cDNA Clone / ORF Clone CG90274-G $95

CD4 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Antigen Recognition>>CD4

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Lineage Markers>>CD4

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells / T Cell Antigen Recognition>>CD4

CD4 Alternative Names

CD4 [Homo sapiens]

Cd4, L3T4, Ly-4 [Mus musculus]

CD4 Background

T-cell surface glycoprotein CD4,  is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.

Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.

CD4 Related Studies

  1. Farrar WL, et al. (1988) Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development. Crit Rev Immunol. 8(4): 315-39.
  2. Biddison WE, et al. (1989) CD4 expression and function in HLA class II-specific T cells. Immunol Rev. 109: 5-15.
  3. Singh SK, et al. (2012) Mapping the interaction between the cytoplasmic domains of HIV-1 viral protein U and human CD4 with NMR spectroscopy. FEBS J. 279(19):3705-14.

 

 

CD4 related areas, pathways, and other information

 

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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