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CD4 / LEU3 Antibody, Rabbit MAb

  • CD4 / LEU3 Antibody, Rabbit MAb, Western blot
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Human CD4 Antibody Product Information
Immunogen:Recombinant Human CD4 protein (Catalog#10400-H08H)
Clone ID:104
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD4 (rh CD4; Catalog#10400-H08H; NP_000607.1; Met 1-Trp 390).
Human CD4 Antibody WB Application Image
Other CD4 Antibody Products
Reactivity: Human  
Application: ELISA  WB  
  • Slide 1
10400-RP02-50
10400-RP02-200
10400-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10400-MM03-50
    10400-MM03-200
    10400-MM03-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10400-RP01-400
      10400-RP01-200
      10400-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: WB  
      • Slide 1
      10400-MM04-50
      10400-MM04-200
      10400-MM04-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      • Slide 1
      10400-MM08-P-25
      10400-MM08-P-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  IHC-P  
      • Slide 1
      • Slide 1
      10400-R113-50
      10400-R113-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      • Slide 1
      10400-MM08-F-25
      10400-MM08-F-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      • Slide 1
      10400-MM08-A-25
      10400-MM08-A-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10400-MM08-C-25
      10400-MM08-C-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10400-MM08-50
      10400-MM08-200
      10400-MM08-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: IHC-P  
      • Slide 1
      • Slide 1
      • Slide 1
      10400-MM22-50
      10400-MM22-200
      10400-MM22-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10400-MM07-50
        10400-MM07-200
        10400-MM07-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  IHC-P  
        • Slide 1
        50134-R001-50
        50134-R001-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50134-RP01-400
          50134-RP01-200
          50134-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50134-T16-50
            50134-T16-200
            50134-T16-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Ferret  
            Application: ELISA  
              60003-MM09-50
              60003-MM09-200
              60003-MM09-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Ferret  
              Application: ELISA  
                60003-R108-50
                60003-R108-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Ferret  
                Application: FCM  
                • Slide 1
                • Slide 1
                60003-MM02-A-25
                60003-MM02-A-100
                25 Test 
                100 Tests 
                Add to Cart
                Reactivity: Ferret  
                Application: FCM  
                • Slide 1
                • Slide 1
                60003-MM02-F-25
                60003-MM02-F-100
                25 Test 
                100 Tests 
                Add to Cart
                Reactivity: Ferret  
                Application: 
                  60003-MM08-50
                  60003-MM08-200
                  60003-MM08-100
                  60003-MM08-1
                  50 µg 
                  200 µg 
                  100 µg 
                  1 mg 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  60003-MM02-50
                  60003-MM02-100
                  60003-MM02-1
                  50 µg 
                  100 µg 
                  1 mg 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  60003-MM02-C-25
                  60003-MM02-C-100
                  25 Test 
                  100 Tests 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  • Slide 1
                  60003-MM02-P-25
                  60003-MM02-P-100
                  25 Test 
                  100 Tests 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: ELISA  
                    60003-RP02-50
                    60003-RP02-200
                    60003-RP02-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    CD4 Background

                    T-cell surface glycoprotein CD4,  is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.

                    Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.

                    Human CD4 References
                  • Farrar WL, et al. (1988) Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development. Crit Rev Immunol. 8(4): 315-39.
                  • Biddison WE, et al. (1989) CD4 expression and function in HLA class II-specific T cells. Immunol Rev. 109: 5-15.
                  • Singh SK, et al. (2012) Mapping the interaction between the cytoplasmic domains of HIV-1 viral protein U and human CD4 with NMR spectroscopy. FEBS J. 279(19):3705-14.
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                    Catalog: 10400-R104-50
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                    Datasheet & Documentation

                    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"