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CD4 Antibody, Rabbit PAb

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    Mouse CD4 Antibody Product Information
    Immunogen:Recombinant Mouse CD4 protein (Catalog#50134-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse CD4 (rM; Catalog#50134-M08H; NP_038516.1; Met 1-Thr 394). Total IgG was purified by Protein A affinity chromatography.
    Other CD4 Antibody Products
    Reactivity: Human  
    Application: IHC-P  
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    10400-MM22-200
    10400-MM22-100
    10400-MM22-50
    200 µg 
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10400-MM03-200
      10400-MM03-50
      10400-MM03-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  
      • Slide 1
      10400-R104-50
      10400-R104-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10400-RP01-400
        10400-RP01-100
        10400-RP01-200
         
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  WB  
        • Slide 1
        10400-RP02-200
        10400-RP02-50
        10400-RP02-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  IHC-P  
        • Slide 1
        • Slide 1
        10400-R113-50
        10400-R113-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10400-MM07-200
          10400-MM07-100
          10400-MM07-50
          200 µg 
          100 µg 
          50 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10400-MM08-F-100
          10400-MM08-F-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10400-MM08-P-100
          10400-MM08-P-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10400-MM08-A-100
          10400-MM08-A-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: WB  
          • Slide 1
          10400-MM04-200
          10400-MM04-100
          10400-MM04-50
          200 µg 
          100 µg 
          50 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10400-MM08-C-100
          10400-MM08-C-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10400-MM08-200
          10400-MM08-100
          10400-MM08-50
          200 µg 
          100 µg 
          50 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50134-T16-200
            50134-T16-100
            50134-T16-50
            200 µg 
            100 µg 
            50 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  IHC-P  
            • Slide 1
            50134-R001-50
            50134-R001-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Ferret  
            Application: ELISA  
              60003-R108-100
              60003-R108-50
              100 µg 
              50 µg 
              Add to Cart
              Reactivity: Ferret  
              Application: ELISA  
                60003-RP02-50
                60003-RP02-100
                60003-RP02-200
                50 µg 
                100 µg 
                200 µg 
                Add to Cart
                Reactivity: Ferret  
                Application: ELISA  
                  60003-MM09-50
                  60003-MM09-100
                  60003-MM09-200
                  50 µg 
                  100 µg 
                  200 µg 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  60003-MM02-F-50
                  60003-MM02-F-100
                  50 Tests 
                  100 Tests 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  60003-MM02-P-50
                  60003-MM02-P-100
                  50 Tests 
                  100 Tests 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  60003-MM02-A-100
                  60003-MM02-A-50
                  100 Tests 
                  50 Tests 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: ELISA  FCM  
                  • Slide 1
                  60003-MM02-100
                  60003-MM02-50
                  100 µg 
                  50 µg 
                  Add to Cart
                  Reactivity: Ferret  
                  Application: FCM  
                  • Slide 1
                  60003-MM02-C-100
                  60003-MM02-C-50
                  100 Tests 
                  50 Tests 
                  Add to Cart
                  CD4 Background

                  T-cell surface glycoprotein CD4,  is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.

                  Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.

                  Mouse CD4 References
                • Farrar WL, et al. (1988) Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development. Crit Rev Immunol. 8(4): 315-39.
                • Biddison WE, et al. (1989) CD4 expression and function in HLA class II-specific T cells. Immunol Rev. 109: 5-15.
                • Singh SK, et al. (2012) Mapping the interaction between the cytoplasmic domains of HIV-1 viral protein U and human CD4 with NMR spectroscopy. FEBS J. 279(19):3705-14.
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                  Catalog: 50134-RP01-400
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                  Datasheet & Documentation

                  All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                  Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"