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CD4  Antibody

All CD4 Reagents

Reactivity: Human  
Application: ELISA  WB  
10400-RP02-50
10400-RP02-200
10400-RP02-100
50 µg 
200 µg 
100 µg 
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  • Slide 1
Reactivity: Human  
Application: ELISA  WB  
10400-R104-50
10400-R104-100
50 µg 
100 µg 
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  • Slide 1
Reactivity: Human  
Application: ELISA  
10400-MM03-50
10400-MM03-200
10400-MM03-100
50 µg 
200 µg 
100 µg 
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    Reactivity: Human  
    Application: ELISA  
    10400-RP01-400
    10400-RP01-200
    10400-RP01-100
    400 µg 
    200 µg 
    100 µg 
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      Reactivity: Human  
      Application: WB  
      10400-MM04-50
      10400-MM04-200
      10400-MM04-100
      50 µg 
      200 µg 
      100 µg 
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      • Slide 1
      Reactivity: Human  
      Application: FCM  
      10400-MM08-P-25
      10400-MM08-P-100
      25 Test 
      100 Tests 
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      • Slide 1
      • Slide 1
      Reactivity: Human  
      Application: ELISA  IHC-P  
      10400-R113-50
      10400-R113-100
      50 µg 
      100 µg 
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      • Slide 1
      • Slide 1
      Reactivity: Human  
      Application: FCM  
      10400-MM08-F-25
      10400-MM08-F-100
      25 Test 
      100 Tests 
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      • Slide 1
      • Slide 1
      Reactivity: Human  
      Application: FCM  
      10400-MM08-A-25
      10400-MM08-A-100
      25 Test 
      100 Tests 
      Add to Cart
      • Slide 1
      • Slide 1
      Reactivity: Human  
      Application: FCM  
      10400-MM08-C-25
      10400-MM08-C-100
      25 Test 
      100 Tests 
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      • Slide 1
      Reactivity: Human  
      Application: FCM  
      10400-MM08-50
      10400-MM08-200
      10400-MM08-100
      50 µg 
      200 µg 
      100 µg 
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      • Slide 1
      Reactivity: Human  
      Application: IHC-P  
      10400-MM22-50
      10400-MM22-200
      10400-MM22-100
      50 µg 
      200 µg 
      100 µg 
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      • Slide 1
      • Slide 1
      • Slide 1
      Reactivity: Human  
      Application: ELISA  
      10400-MM07-50
      10400-MM07-200
      10400-MM07-100
      50 µg 
      200 µg 
      100 µg 
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        Reactivity: Mouse  
        Application: ELISA  IHC-P  
        50134-R001-50
        50134-R001-100
        50 µg 
        100 µg 
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        • Slide 1
        Reactivity: Mouse  
        Application: ELISA  
        50134-RP01-400
        50134-RP01-200
        50134-RP01-100
        400 µg 
        200 µg 
        100 µg 
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          Reactivity: Mouse  
          Application: ELISA  
          50134-T16-50
          50134-T16-200
          50134-T16-100
          50 µg 
          200 µg 
          100 µg 
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            Reactivity: Ferret  
            Application: ELISA  
            60003-MM09-50
            60003-MM09-200
            60003-MM09-100
            50 µg 
            200 µg 
            100 µg 
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              Reactivity: Ferret  
              Application: ELISA  
              60003-R108-50
              60003-R108-100
              50 µg 
              100 µg 
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                Reactivity: Ferret  
                Application: FCM  
                60003-MM02-A-25
                60003-MM02-A-100
                25 Test 
                100 Tests 
                Add to Cart
                • Slide 1
                • Slide 1
                Reactivity: Ferret  
                Application: FCM  
                60003-MM02-F-25
                60003-MM02-F-100
                25 Test 
                100 Tests 
                Add to Cart
                • Slide 1
                • Slide 1
                Reactivity: Ferret  
                Application: 
                60003-MM08-50
                60003-MM08-200
                60003-MM08-100
                60003-MM08-1
                50 µg 
                200 µg 
                100 µg 
                1 mg 
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                  Reactivity: Ferret  
                  Application: FCM  
                  60003-MM02-50
                  60003-MM02-100
                  60003-MM02-1
                  50 µg 
                  100 µg 
                  1 mg 
                  Add to Cart
                  • Slide 1
                  Reactivity: Ferret  
                  Application: FCM  
                  60003-MM02-C-25
                  60003-MM02-C-100
                  25 Test 
                  100 Tests 
                  Add to Cart
                  • Slide 1
                  Reactivity: Ferret  
                  Application: FCM  
                  60003-MM02-P-25
                  60003-MM02-P-100
                  25 Test 
                  100 Tests 
                  Add to Cart
                  • Slide 1
                  • Slide 1
                  Reactivity: Ferret  
                  Application: ELISA  
                  60003-RP02-50
                  60003-RP02-200
                  60003-RP02-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart

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                    CD4 Related Area

                    CD4 Related Pathways

                    CD4 Summary & Protein Information

                    CD4 Background

                    Gene Summary: CD4 gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This CD4 gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. CD4 functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this CD4 gene.
                    General information above from NCBI
                    Subunit structure: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120. {ECO:0000269|PubMed:11113139, ECO:0000269|PubMed:16331979, ECO:0000269|PubMed:18078954, ECO:0000269|PubMed:2214026, ECO:0000269|PubMed:7909607, ECO:0000269|PubMed:9641677}.
                    Subcellular location: Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
                    Post-translational: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. {ECO:0000269|PubMed:1618861}.
                    Sequence similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
                    General information above from UniProt

                    T-cell surface glycoprotein CD4,  is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.

                    Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.

                    CD4 Alternative Name

                    CD4mut, []
                    CD4mut, [homo-sapiens]
                    CD4, [human]
                    Cd4,L3T4,Ly-4, [mouse]
                    L3T4,Ly-4, [mus-musculus]

                    CD4 Related Studies

                  • Farrar WL, et al. (1988) Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development. Crit Rev Immunol. 8(4): 315-39.
                  • Biddison WE, et al. (1989) CD4 expression and function in HLA class II-specific T cells. Immunol Rev. 109: 5-15.
                  • Singh SK, et al. (2012) Mapping the interaction between the cytoplasmic domains of HIV-1 viral protein U and human CD4 with NMR spectroscopy. FEBS J. 279(19):3705-14.
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