CD3e Protein & Antibody (CD3 epsilon)

Cluster of Differentiation 3e (T-cell surface glycoprotein CD3 epsilon chain)

CD3e Products

CD3e Protein, Recombinant

Molecule	Species	Description	Cat. No
CD3e/CD3 epsilon	Human	CD3e Protein, Recombinant	10977-H08H
CD3e/CD3 epsilon	Cynomolgus	CD3E Protein, Recombinant	90047-C02H

  10977-H08H: Measured by its ability to bind recombinant human CD3D in a functional ELISA.

CD3e Antibody Products

Molecule	Application	Description	Cat. No
Human CD3e/CD3 epsilon	WB, ELISA	CD3e/CD3 epsilon Antibody, Mouse MAb	10977-MM03

CD3e cDNA Clone

Molecule	Species	Description	Cat. No
CD3e/CD3 epsilon	Human	Homo sapiens CD3e cDNA Clone(NM_000733.3)	HG10977-M
CD3e/CD3 epsilon	Mouse	Mus musculus CD3e cDNA Clone	MG50410-M
CD3e/CD3 epsilon	Cynomolgus	CD3E cDNA Clone / ORF Clone	KG90047-G

CD3e Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD3e

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Antigen Recognition>>CD3e

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Antigen Recognition>>CD3e

CD3e Alternative Names

CD3E, CD3-epsilon, FLJ18683, T3E, TCRE [Homo sapiens]

CD3e, CD3epsilon, CD3, T3e, AI504783 [Mus musculus]

CD3e Background

T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

CD3e Related Studies

1. Fischer A, et al. (2005) CD3 deficiencies. Curr Opin Allergy Clin Immunol. 5(6): 491-5.
2. Wang Y, et al. (2009) A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 7(12): e1000253.
3. Martínez-Martín N, et al. (2009) Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon. Sci Signal. 2(83): ra43.
4. Deford-Watts LM, et al. (2009) The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 183(2): 1055-64.