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CD3e/CD3 epsilon  Antibody

All CD3e Reagents

Reactivity: Human  
Application: ELISA  
    10977-R822-50
    10977-R822-100
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10977-T16-50
      10977-T16-100
      10977-T16-200
      50 µg 
      100 µg 
      200 µg 
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      Reactivity: Human  
      Application: WB  IP  
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      10977-R801-50
      10977-R801-100
      50 µg 
      100 µg 
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      Reactivity: Human  
      Application: FCM  Func/A  
      • Slide 1
      • Slide 1
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      10977-H001-100
      10977-H001-1
      100 µg 
      1 mg 
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      Reactivity: Human  
      Application: ELISA  IP  
      • Slide 1
      10977-T20-100
      10977-T20-50
      10977-T20-200
      100 µg 
      50 µg 
      200 µg 
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      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10977-R301-A-50
      10977-R301-A-100
      50 Tests 
      100 Tests 
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      Reactivity: Human  
      Application: ELISA  
        10977-MM03-50
        10977-MM03-100
        50 µg 
        100 µg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10977-M001-C-100
        10977-M001-C-50
        100 Tests 
        50 Tests 
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        Reactivity: Human  
        Application: WB  
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        100216-T32-200
        100216-T32-100
        100216-T32-50
        200 µg 
        100 µg 
        50 µg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10977-M001-100
        10977-M001-50
        10977-M001-200
        100 µg 
        50 µg 
        200 µg 
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        Reactivity: Human  
        Application: ELISA  
          10977-RP01-200
          10977-RP01-100
          10977-RP01-400
          200 µg 
          100 µg 
           
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10977-M001-F-100
          10977-M001-F-50
          100 Tests 
          50 Tests 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10977-M001-P-100
          10977-M001-P-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10977-M001-A-100
          10977-M001-A-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10977-R301-F-50
          10977-R301-F-100
          50 Tests 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  IHC-P  
          • Slide 1
          • Slide 1
          • Slide 1
          10977-R301-100
          10977-R301-50
          100 µg 
          50 µg 
          Add to Cart

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          CD3e/CD3 epsilon Related Pathways

          CD3e/CD3 epsilon Summary & Protein Information

          CD3e/CD3 epsilon Background

          Gene Summary: The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
          General information above from NCBI
          Subunit structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
          Subcellular location: Membrane; Single-pass type I membrane protein.
          Sequence similarity: Contains 1 Ig-like (immunoglobulin-like) domain.
          Contains 1 ITAM domain.
          General information above from UniProt

          T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

          CD3e/CD3 epsilon Alternative Name

          T3E,TCRE,IMD18, [homo-sapiens]
          CD3E,CD3-epsilon,FLJ18683,T3E,TCRE, [human]
          Cd3,AI504783,CD3e,CD3epsilon,T3e, [mouse]
          CD3,T3e,AI504783,CD3epsilon, [mus-musculus]

          CD3e/CD3 epsilon Related Studies

        • Fischer A, et al. (2005) CD3 deficiencies. Curr Opin Allergy Clin Immunol. 5(6): 491-5.
        • Wang Y, et al. (2009) A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol. 7(12): e1000253.
        • Martnez-Martn N, et al. (2009) Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon. Sci Signal. 2(83): ra43.
        • Deford-Watts LM, et al. (2009) The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 183(2): 1055-64.
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