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CD3g/CD3 gamma  Protein, Antibody, ELISA Kit, cDNA Clone

CD3g/CD3 gamma Related Area

CD3g/CD3 gamma Related Pathways

CD3g/CD3 gamma Summary & Protein Information

CD3g/CD3 gamma Background

Subunit structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. {ECO:0000269|PubMed:15136729}.
Domain: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
Subcellular location: Membrane; Single-pass type I membrane protein.
Involvement in disease: DISEASE: Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269|PubMed:1635567, ECO:0000269|PubMed:17277165}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 1 Ig-like (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 ITAM domain. {ECO:0000255|PROSITE-ProRule:PRU00379}.
General information above from UniProt

CD3G gene encodes CD3-gamma polypeptide, which together with CD3-epsilon, -delta, and -zeta, and the TCR alpha/beta and gamma/delta heterodimers, forms the TCR-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The CD3 gamma chain has long been considered to mediate targeting to lysosomes for degradation. Defects in this gene are associated with T cell immunodeficiency. Further, it has been proposed as one of the important candidate genes for cancer development due to its pivotal roles in TCR signaling pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

CD3g/CD3 gamma Alternative Name

T3G,IMD17,CD3-GAMMA, [homo-sapiens]
T3g,Ctg3,Ctg-3, [mus-musculus]

CD3g/CD3 gamma Related Studies

  • Jiang L, Xu J, Ni J, et al. A Functional Insertion/Deletion Polymorphism in the Proximal Promoter of CD3G Is Associated with Susceptibility for Hepatocellular Carcinoma in Chinese Population. DNA and Cell Biology.