- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
CD3 antigen, delta polypeptide Protein Datasheet
CD3D Protein Price Inquiry ( Available Sizes )
CD3D Protein Product Information
|Synonym :||CD3D, T3d|
|Protein Construction:||A DNA sequence encoding the mouse CD3D (P04235) (Met1- Ala105) was expressed, fused with the Fc region of human IgG1 at the C-terminus.|
|Expression Host:||Human Cells|
CD3D Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Phe 22|
The recombinant mouse CD3D/Fc is a disulfide-linked homodimer. The reduced monomer comprises 325 amino acids and has a predicted molecular mass of 36.4 kDa. The apparent molecular mass of the protein is approximately 44-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4
CD3D Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CD3D Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD3d/CD3 delta||Human||CD3d Protein, Recombinant||10981-H08H|
|CD3d/CD3 delta||Human||CD3D / CD3-Delta Protein, Recombinant, with flag Tag||10981-H23H|
|CD3d/CD3 delta||Mouse||CD3D Protein, Recombinant||50390-M02H|
|CD3d/CD3 delta||Cynomolgus||CD3D Protein, Recombinant||90046-C02H|
|CD3d/CD3 delta||Cynomolgus||CD3D Protein, Recombinant||90046-C08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||CD3d / CD3 delta Antibody||10981-MM06|
|WB, ELISA||Mouse Monoclonal Antibody||10981-MM08|
|WB, ELISA||CD3d Antibody, Rabbit MAb||10981-R006|
|WB, ELISA||Rabbit Polyclonal Antibody||10981-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10981-RP02|
CD3D Protein Description
T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative / B-cell-positive / NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
- Doucey MA. et al., 2003, J Biol Chem. 278 (5): 3257-64.
- Call ME. et al., 2004, EMBO J. 23 (12): 2348-57.
- Arnett KL. et al., 2004, Proc Natl Acad Sci. 101: 16268-73.
- Kjer-Nielsen L. et al., 2004, Proc Natl Acad Sci. 101: 7675-80.
- Fischer A. et al., 2005, Curr Opin Allergy Clin Immunol. 5 (6): 491-5.
- Holst J. et al., 2008, Nature immunology. 9 (6): 658-66.