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Mouse CD3d / CD3 delta Protein (Fc Tag)
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Mouse CD3d / CD3 delta Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50390-M02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

CD3 antigen, delta polypeptide Protein Datasheet

 

CD3D Protein Price Inquiry ( Available Sizes )

CD3D Protein Product Information

Synonym : CD3D, T3d
Protein Construction: A DNA sequence encoding the mouse CD3D (P04235) (Met1- Ala105) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source: Mouse
Expression Host: Human Cells

CD3D Protein QC Testing

Purity: > 95% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

CD3D protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Phe 22
Molecular Mass:

The recombinant mouse CD3D/Fc is a disulfide-linked homodimer. The reduced monomer comprises 325 amino acids and has a predicted molecular mass of 36.4 kDa. The apparent molecular mass of the protein is approximately 44-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

CD3D Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD3D Protein Related Products & Topics

Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>CD3d

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>CD3d

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>CD3d

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD3d/CD3 delta Human CD3d Protein, Recombinant 10981-H08H
CD3d/CD3 delta Human CD3D / CD3-Delta Protein, Recombinant, with flag Tag 10981-H23H
CD3d/CD3 delta Mouse CD3D Protein, Recombinant 50390-M02H
CD3d/CD3 delta Cynomolgus CD3D Protein, Recombinant 90046-C02H
CD3d/CD3 delta Cynomolgus CD3D Protein, Recombinant 90046-C08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD3d
WB, ELISA CD3d / CD3 delta Antibody 10981-MM06
Human
CD3d
WB, ELISA Mouse Monoclonal Antibody 10981-MM08
Human
CD3d
WB, ELISA CD3d Antibody, Rabbit MAb 10981-R006
Human
CD3d
WB, ELISA Rabbit Polyclonal Antibody 10981-RP01
Human
CD3d
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10981-RP02

CD3D Protein Description

T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative / B-cell-positive / NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

References

  1. Doucey MA. et al., 2003, J Biol Chem. 278 (5): 3257-64.
  2. Call ME. et al., 2004, EMBO J. 23 (12): 2348-57.
  3. Arnett KL. et al., 2004, Proc Natl Acad Sci. 101: 16268-73.
  4. Kjer-Nielsen L. et al., 2004, Proc Natl Acad Sci. 101: 7675-80.
  5. Fischer A. et al., 2005, Curr Opin Allergy Clin Immunol. 5 (6): 491-5.
  6. Holst J. et al., 2008, Nature immunology. 9 (6): 658-66.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"