CD3D Protein, Human, Recombinant (Fc & FLAG Tag)

Cat: 10981-H23H

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CD3D Protein, Human, Recombinant (Fc & FLAG Tag) Product Information
> 85 % as determined by SDS-PAGE
< 1.0 EU per μg of the protein as determined by the LAL method
Testing in progress
Protein Construction
A DNA sequence encoding the human CD3D (Met1-Ala105) was fused with the C-terminal flag-tagged Fc region of human IgG1 at the C-terminus.
Expressed Host
HEK293 Cells
Predicted N Terminal
Phe 22
Molecule Mass
The recombinant human CD3D consists of 335 amino acids and predicts a molecular mass of 37.8 KDa. It migrates as an approximately 47-51 KDa band in SDS-PAGE under reducing conditions.
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD3D Protein, Human, Recombinant (Fc & FLAG Tag) in SDS-PAGE
Human CD3d/CD3 delta Protein 9270
CD3D Protein, Human, Recombinant (Fc & FLAG Tag) Alternative Names
CD3 delta Protein, Human;CD3-DELTA Protein, Human;IMD19 Protein, Human;T3D Protein, Human
CD3D Background Information

T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The majority of T cell receptor (TCR) complexes in mice and humans consist of a heterodimer of polymorphic TCRalpha and beta chains along with invariant CD3gamma, delta, epsilon, and zeta chains. CD3 chains are present as CD3gammaepsilon, deltaepsilon, and zetazeta dimers in the receptor complex and play critical roles in the antigen receptor assembly, transport to the cell surface, and the receptor-mediated signal transduction. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. In the mouse, knockout of CD3delta allows some degree of T lymphocyte differentiation since mature CD4 and CD8 as well as TCRgammadelta T lymphocytes are observed in the periphery. In contrast, deleterious mutation of the CD3delta encoding gene in the human leads to a severe combined immunodeficiency characterised by the complete absence of mature T cell subpopulations including TCRalpha/beta and TCRgamma/delta. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. In humans the absence of CD3 delta results in a complete arrest in thymocyte development at the stage of double negative to double positive transition and the development of gamma delta T-cell receptor-positive T cells is also impaired.

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Full Name
CD3d molecule, delta (CD3-TCR complex)
  • Roifman CM. (2004) CD3 delta immunodeficiency. Curr Opin Allergy Clin Immunol. 4(6): 479-84.
  • Pan Q, et al. (2006) Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice. Mol Immunol. 43(11): 1741-50.
  • Le Deist F, et al. (2007) Expression anomalies of the CD3-TCR complex expression and immunodeficiencies. Med Sci (Paris). 23(2): 161-6.
  • Other CD3D Proteins

    Cynomolgus CD3D Proteins

    Product Name Cat.No.
    CD3D Protein, Cynomolgus, Recombinant (Fc Tag) 90046-C02H
    CD3D Protein, Cynomolgus, Recombinant (His Tag) 90046-C08H

    Canine CD3D Proteins

    Product Name Cat.No.
    CD3D Protein, Canine, Recombinant (Fc Tag) 70108-D02H

    Mouse CD3D Proteins

    Product Name Cat.No.
    CD3D Protein, Mouse, Recombinant (Fc Tag) 50390-M02H

    Human CD3D Proteins

    Product Name Cat.No.
    CD3D Protein, Human, Recombinant (His Tag) 10981-H08H
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