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>Human Cell Expressed
>Human CD3d / CD3 delta Protein (Fc & FLAG Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
CD3d molecule, delta (CD3-TCR complex) Protein Datasheet
CD3D / CD3-Delta Protein Price Inquiry ( Available Sizes )
CD3D / CD3-Delta Protein Product Information
|Protein Construction:||A DNA sequence encoding the human CD3D (Met1-Ala105) was fused with the C-terminal flag-tagged Fc region of human IgG1 at the C-terminus|
|Expression Host:||Human Cells|
CD3D / CD3-Delta Protein QC Testing
|Purity:||> 85% as determined by SDS-PAGE||SDS-PAGE:
CD3D / CD3-Delta protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Phe 22|
The recombinant human CD3D consists of 335 amino acids and predicts a molecular mass of 37.8 KDa. It migrates as an approximately 47-51 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
CD3D / CD3-Delta Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CD3D / CD3-Delta Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD3d/CD3 delta||Human||CD3d Protein, Recombinant||10981-H08H|
|CD3d/CD3 delta||Human||CD3D / CD3-Delta Protein, Recombinant, with flag Tag||10981-H23H|
|CD3d/CD3 delta||Mouse||CD3D Protein, Recombinant||50390-M02H|
|CD3d/CD3 delta||Cynomolgus||CD3D Protein, Recombinant||90046-C02H|
|CD3d/CD3 delta||Cynomolgus||CD3D Protein, Recombinant||90046-C08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||CD3d / CD3 delta Antibody||10981-MM06|
|WB, ELISA||Mouse Monoclonal Antibody||10981-MM08|
|WB, ELISA||CD3d Antibody, Rabbit MAb||10981-R006|
|WB, ELISA||Rabbit Polyclonal Antibody||10981-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||10981-RP02|
CD3D / CD3-Delta Protein Description
T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative / B-cell-positive / NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
- Doucey MA. et al., 2003, J Biol Chem. 278 (5): 3257-64.
- Call ME. et al., 2004, EMBO J. 23 (12): 2348-57.
- Arnett KL. et al., 2004, Proc Natl Acad Sci. 101: 16268-73.
- Kjer-Nielsen L. et al., 2004, Proc Natl Acad Sci. 101: 7675-80.
- Fischer A. et al., 2005, Curr Opin Allergy Clin Immunol. 5 (6): 491-5.
- Holst J. et al., 2008, Nature immunology. 9 (6): 658-66.