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Human CD3d / CD3 delta Protein (Fc & FLAG Tag)
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Human CD3d / CD3 delta Protein (Fc & FLAG Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
10981-H23H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

CD3d molecule, delta (CD3-TCR complex) Protein Datasheet

 

CD3D / CD3-Delta Protein Price Inquiry ( Available Sizes )

CD3D / CD3-Delta Protein Product Information

Synonym : CD3D
Protein Construction: A DNA sequence encoding the human CD3D (Met1-Ala105) was fused with the C-terminal flag-tagged Fc region of human IgG1 at the C-terminus
Source: Human
Expression Host: Human Cells

CD3D / CD3-Delta Protein QC Testing

Purity: > 85% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

CD3D / CD3-Delta protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Phe 22
Molecular Mass:

The recombinant human CD3D consists of  335 amino acids and predicts a molecular mass of 37.8 KDa. It migrates as an approximately 47-51 KDa band in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

CD3D / CD3-Delta Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD3D / CD3-Delta Protein Related Products & Topics

Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>CD3d

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>CD3d

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>CD3d

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD3d/CD3 delta Human CD3d Protein, Recombinant 10981-H08H
CD3d/CD3 delta Human CD3D / CD3-Delta Protein, Recombinant, with flag Tag 10981-H23H
CD3d/CD3 delta Mouse CD3D Protein, Recombinant 50390-M02H
CD3d/CD3 delta Cynomolgus CD3D Protein, Recombinant 90046-C02H
CD3d/CD3 delta Cynomolgus CD3D Protein, Recombinant 90046-C08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD3d
WB, ELISA CD3d / CD3 delta Antibody 10981-MM06
Human
CD3d
WB, ELISA Mouse Monoclonal Antibody 10981-MM08
Human
CD3d
WB, ELISA CD3d Antibody, Rabbit MAb 10981-R006
Human
CD3d
WB, ELISA Rabbit Polyclonal Antibody 10981-RP01
Human
CD3d
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10981-RP02

CD3D / CD3-Delta Protein Description

T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative / B-cell-positive / NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

References

  1. Doucey MA. et al., 2003, J Biol Chem. 278 (5): 3257-64.
  2. Call ME. et al., 2004, EMBO J. 23 (12): 2348-57.
  3. Arnett KL. et al., 2004, Proc Natl Acad Sci. 101: 16268-73.
  4. Kjer-Nielsen L. et al., 2004, Proc Natl Acad Sci. 101: 7675-80.
  5. Fischer A. et al., 2005, Curr Opin Allergy Clin Immunol. 5 (6): 491-5.
  6. Holst J. et al., 2008, Nature immunology. 9 (6): 658-66.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"