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Rat CD38 Protein (Fc Tag)
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Rat CD38 Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80229-R02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

CD38 molecule Protein Datasheet

 

CD38 Protein Price Inquiry ( Available Sizes )

CD38 Protein Product Information

Synonym : CD38
Protein Construction:

A DNA sequence encoding the rat CD38 (Q64244) (Trp45-Val303) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Rat
Expression Host: Human Cells

CD38 Protein QC Testing

Purity: > 95% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

CD38 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Trp 45
Molecular Mass:

The recombinant rat CD38 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 500 amino acids and has a predicted molecular mass of 56.7 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

CD38 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD38 Protein Related Products & Topics

Related Areas:

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>CD38

Cancer>>Cancer Stem Cell (CSC)>>CD38

Cancer>>Cancer Biomarkers>>CD38

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD38

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD38

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD38

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD38

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD38 Human CD38 Protein, Recombinant 10818-H08H
CD38 Human CD38 Protein, Recombinant, with Gflag Tag 10818-H32H
CD38 Mouse CD38 Protein, Recombinant 50191-M08H
CD38 Rat CD38 Protein, Recombinant 80229-R02H
CD38 Rat CD38 Protein, Recombinant 80229-R08H
CD38 Cynomolgus CD38 Protein, Recombinant 90050-C02H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD38
ELISA Mouse Monoclonal Antibody 10818-MM03
Human
CD38
WB Mouse Monoclonal Antibody 10818-MM04
Human
CD38
WB, ELISA CD38 Antibody, Rabbit MAb 10818-R011
Human
CD38
WB, ELISA Rabbit Polyclonal Antibody 10818-RP01
Human
CD38
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10818-RP02
Mouse
CD38
WB, ELISA Rabbit Monoclonal Antibody 50191-R032
Mouse
CD38
WB, ELISA Rabbit Polyclonal Antibody 50191-RP01
Mouse
CD38
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 50191-RP02

CD38 Protein Description

CD38, also known as ADP-ribosyl cyclase, is a transmembrane glycoprotein comprising two to four N-linked oligosaccharide chains containing sialic acid residues. It is expressed on the surface of immune cells including CD4+, CD8+, B and natural killer cells. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. CD38 functions in cell adhesion, signal transduction and calcium signaling. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic β cells. CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders. Defects of CD38 is associated with impaired immune responses, metabolic disturbances, and behavioral modifications, and has been connected to human immunodeficiency virus (HIV) infection, leukemias, myelomas, solid tumors, type I I diabetes mellitus and bone metabolism, as well as some genetically determined conditions. In addition, it was demonstrated that CD38 not only acts as a key modulator of the immune response, but also plays an equally important role as an intrinsic pulmonary component. CD38 as the main cellular NADase in mammalian tissues, and the characterization of its role on the control of cellular NAD levels indicate that CD38 may serve as a pharmacological target for multiple conditions.

References

  1. Deaglio S. et al., 2001, Leuk Res. 25 (1): 1-12.
  2. Jin D. et al., 2007, Nature. 446 (7131): 41-5.
  3. Orciani M. et al., 2008, J Cell Biochem. 105 (3): 905-12.
  4. Malavasi F. et al., 2008, Physiol Rev. 88 (3): 841-86.
  5. Chini EN. et al., 2009, Curr Pharm Des. 15 (1): 57-63.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"