CD38 Antibody (Rabbit Monoclonal Antibody)

CD38 Antibody Datasheet

CD38 Antibody Product Information

• Immunogen: Recombinant human CD38 protein ( Catalog#10818-H08H )
• Antibody Type: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
• Clone ID: 11
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CD38 ( rhCD38 ; Catalog#10818-H08H; NP_001766.2 ; Val 43-Ile 300).

CD38 Antibody Usage Guide

• Specificity: Human CD38
• Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect human CD38 in WB. Using a DAB detection system, the detection limit for human CD38 is approximately 0.0625 ng/lane under non-reducing conditions and reducing conditions
• Direct ELISA: This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect human CD38. The detection limit for human CD38 is 0.00245 ng/well
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

CD38 Antibody Background

CD38 (cluster of differentiation 38), also known as ADP-ribosyl cyclase, is a glycoprotein expressed on the surface of immune cells including B and T lymphocytes, osteoclasts, as well as cardiac, pancreatic, liver and kidney cells. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic β cells. CD38 functions in cell adhesion, signal transduction and calcium signaling. Defects of CD38 is associated with impaired immune responses, metabolic disturbances, and behavioral modifications, and thus has been connected to HIV infection, leukemias, myelomas, solid tumors, type I I diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

References

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