CD33 / Siglec-3 Protein

Cluster of Differentiation 33

CD33 / Siglec-3 Products

CD33 / Siglec-3 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD33/Siglec-3	Mouse	CD33 Protein, Recombinant	50712-M02H
CD33/Siglec-3	Mouse	CD33 Protein, Recombinant	50712-M08H

CD33 / Siglec-3 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD33/Siglec-3	Mouse	Mouse CD33 cDNA Clone / ORF Clone	MG50712-G
CD33/Siglec-3	Cynomolgus	Cynomolgus monkey CD33 Gene cDNA Clone / ORF Clone	CG90183-G

CD33 / Siglec-3 Related Areas

Adhesion Molecule>>Lectin>>CD33/Siglec-3

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>CD33/Siglec-3

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD33/Siglec-3

CD33 / Siglec-3 Alternative Names

CD33, SIGLEC-3, SIGLEC3, gp67, FLJ00391, p67 [Homo sapiens]

CD33, Siglec-3, gp67 [Mus musculus]

CD33 / Siglec-3 Background

Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.

CD33 / Siglec-3 Related Studies

1. Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
2. Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
3. Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.
4. Sievers EL, et al. (2001) Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol. 19(13): 3244-54.