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CD32/Fc gamma RII/FCGR2  Protein

All CD32 Reagents

Expression host: Human Cells  
50030-M08H-50
50030-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
50030-M27H-B-50
50030-M27H-B-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
50030-M27H-50
50030-M27H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

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CD32/Fc gamma RII/FCGR2 Related Area

CD32/Fc gamma RII/FCGR2 Related Pathways

    CD32/Fc gamma RII/FCGR2 Summary & Protein Information

    CD32/Fc gamma RII/FCGR2 Background

    Gene Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene
    General information above from NCBI

    Receptors for Fc portion of IgG (Fcγ Rs) are members of the Ig superfamily, and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). CD32 protein is a low affinity receptor for IgG that binds only IgG immune complexes and is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94-99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. CD32 is involved in a number of immune responses including antibody-dependent cell-mediated cytotoxicity, clearance of immune complexes, release of inflammatory mediators, and regulation of antibody production.

    CD32/Fc gamma RII/FCGR2 Alternative Name

    CD32/Fc gamma RII/FCGR2 Related Studies

  • Williams TE, et al. (2000) Concurrent and independent binding of Fcgamma receptors IIa and IIIb to surface-bound IgG. Biophys J. 79(4): 1867-75.
  • Kanters D, et al. (2007) Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects. J Allergy Clin Immunol. 120(5): 1073-81.
  • Veri MC, et al. (2007) Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization. Immunology. 121(3): 392-404.
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