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CD32 Protein & Antibody (CDw32, FCGR2, FCGRII)

Cluster of differentiation 32 (Fc gamma Receptor II / FCGRII / FCGR2)

CD32 / FCGRII / Fc gamma Receptor II / Protein & Antibody

CD32 / FCGRII / Fc gamma Receptor II Protein, Recombinant (All Fc receptor Proteins)

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat &
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 Arg) 10374-H08H
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (166 Arg) 10374-H08B
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 Arg) 10374-H02H
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 His) 10374-H08H1
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 His) 10374-H27H1
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 Arg) 10374-H27H
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 His) 10374-H27H1-B
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 Arg) 10374-H27H-B
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein (167 Arg) 10374-H08C
CD32a / FCGR2A /
FCGRIIA
Human CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA   Protein(167 His) 10374-H08C1
CD32a / FCGR2A /
FCGRIIA
Cynomolgus CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein 90015-C08H
CD32a / FCGR2A /
FCGRIIA
Cynomolgus CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein 90015-C27H
CD32a / FCGR2A /
FCGRIIA
Cynomolgus CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein 90015-C27H-B
CD32a / FCGR2A /
FCGRIIA
Cynomolgus CD32a / FCGR2A / FCGRIIA / Fc gamma RIIA Protein 90016-C08H
CD32b / FCGR2B /
FCGRIIB
Human CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 10259-H08H
CD32b / FCGR2B /
FCGRIIB
Human CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 10259-H27H
CD32b / FCGR2B /
FCGRIIB
Human CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 10259-H27H-B
CD32b / FCGR2B /
FCGRIIB
Human CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein  10259-H08C
CD32b / FCGR2B /
FCGRIIB
Mouse CD32 / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 50030-M08H
CD32b / FCGR2B /
FCGRIIB
Mouse CD32 / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 50030-M27H
CD32b / FCGR2B /
FCGRIIB
Mouse CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 50030-M27H-B
CD32b / FCGR2B /
FCGRIIB
Rat CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 80018-R08H
CD32b / FCGR2B /
FCGRIIB
Cynomolgus CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 90014-C08H
CD32b / FCGR2B /
FCGRIIB
Cynomolgus CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 90014-C27H
CD32b / FCGR2B /
FCGRIIB
Cynomolgus CD32b / FCGR2B / FCGRIIB / Fc gamma RIIB Protein 90014-C27H-B

CD32 / FCGRII / Fc gamma Receptor II Antibody (All Fc receptor Antibody)

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat &
Human CD32a /
FCGR2a / FCGRIIA
ELISA Anti-human CD32a / FCGRIIA / Fc gamma RIIA Antibody,
Mouse Mab
10374-MM01
Human CD32a /
FCGR2a / FCGRIIA
ELISA Anti-human CD32a / FCGRIIA / Fc gamma RIIA Antibody,
Mouse Mab
10374-MM02
Human CD32a /
FCGR2a / FCGRIIA
WB, ELISA Anti-human CD32a / FCGRIIA / Fc gamma RIIA Antibody,
Mouse Mab
10374-MM03
Human CD32a /
FCGR2a / FCGRIIA
ELISA, IHC-P Anti-human CD32a / FCGRIIA / Fc gamma RIIA Antibody,
Mouse Mab
10374-MM05
Human CD32a /
FCGR2a / FCGRIIA
WB, ELISA Anti-human CD32a / FCGRIIA / Fc gamma RIIA Antibody,
Rabbit Pab
10374-RP01
Human CD32a /
FCGR2a / FCGRIIA
WB, ELISA Anti-human CD32a / FCGRIIA / Fc gamma RIIA Antibody,
Rabbit Pab (Antigen Affinity Purified)
10374-RP02
Cynomolgus
CD32a / FCGR2a /
FCGRIIA
WB, ELISA Anti-cynomolgus CD32a / Fc gamma RIIA Antibody,
Rabbit Pab (Antigen Affinity Purified)
90015-RP02
Cynomolgus
CD32a / FCGR2a /
FCGRIIA
WB, ELISA Anti-cynomolgus CD32a / Fc gamma RIIA / FCGR2A Antibody,
Rabbit Pab (Antigen Affinity Purified)
90016-RP02
Cynomolgus
CD32a / FCGR2a /
FCGRIIA
WB, ELISA Anti-cynomolgus CD32a / Fc gamma RIIA Antibody,
Mouse Mab
90015-MM06
Cynomolgus
CD32a / FCGR2a /
FCGRIIA
WB, ELISA Anti-cynomolgus CD32a / Fc gamma RIIA / FCGR2A
Antibody,Mouse Mab
90016-MM01
Cynomolgus
CD32a / FCGR2a /
FCGRIIA
ELISA Anti-cynomolgus CD32a / Fc gamma RIIA / FCGR2A
Antibody,Rabbit Mab
90016-R148
Cynomolgus
CD32a / FCGR2a /
FCGRIIA
ELISA Anti-cynomolgus CD32a / Fc gamma RIIA / FCGR2A
Antibody, Rabbit Mab
90016-R085
Human CD32b /
FCGR2b / FCGRIIB
WB, ELISA Anti-human CD32b / FCGRB/Fc gamma RIIB Antibody,
Rabbit Pab
10259-RP01
Human CD32b /
FCGR2b / FCGRIIB
WB, ELISA Anti-human CD32b / FCGRB/Fc gamma RIIB Antibody,
Rabbit Pab (Antigen Affinity Purified)
10259-RP03
Human CD32b /
FCGR2b / FCGRIIB
WB, ELISA, IHC-P, FCM Anti-human CD32b / FCGRIIB / Fc gamma RIIB Antibody,
Rabbit Mab
10259-R110
Human CD32b /
FCGR2b / FCGRIIB
ELISA Anti-human CD32b / FCGRIIB / Fc gamma RIIB Antibody,
Rabbit Mab
10259-R112
Human CD32b /
FCGR2b / FCGRIIB
FCM Anti-human CD32b / FCGRIIB / Fc gamma RIIB Antibody
(FITC), Rabbit Mab
10259-R112-F
Human CD32b /
FCGR2b / FCGRIIB
WB, ELISA Anti-human CD32b / FCGRIIB / Fc gamma RIIB Antibody,
Mouse Mab
10259-MM02
Mouse CD32b /
FCGR2b / FCGRIIB
ELISA Anti-mouse CD32 / FCGR2B Antibody,Rabbit Pab
(Antigen Affinity Purified)
50030-RP02
Mouse CD32b /
FCGR2b / FCGRIIB
WB, ELISA Anti -mouse FCGR2B / CD32 Antibody, Rabbit Mab 50030-R005
Mouse CD32b /
FCGR2b / FCGRIIB
WB, ELISA Anti-mouse CD32b / FCGR2B Antibody, Rabbit Pab 50030-RP01
Rat CD32b /
FCGR2b / FCGRIIB
WB, ELISA Anti-rat CD32b /FCGRIIB/ Fc gamma RIIB Antibody,
Rabbit Pab
80018-RP01
Rat CD32b /
FCGR2b / FCGRIIB
ELISA, IHC-P Anti-rat CD32b /FCGRIIB/ Fc gamma RIIB Antibody,
Rabbit Pab (Antigen Affinity Purified)
80018-RP02
Cynomolgus
CD32b / FCGR2b /
FCGRIIB
WB, ELISA Anti-cynomolgus CD32b / Fc gamma RIIB Antibody,
Rabbit Pab
90014-RP02
Cynomolgus
CD32b / FCGR2b /
FCGRIIB
WB, ELISA Anti-cynomolgus CD32b / Fc gamma RIIB Antibody,
Mouse Mab
90014-MM03
Cynomolgus
CD32b / FCGR2b /
FCGRIIB
ELISA Anti-cynomolgus CD32b / Fc gamma RIIB Antibody,
Rabbit Mab
90014-R046

CD32 / FCGRII / Fc gamma Receptor II cDNA Clone (All Fc receptor gene cDNA Clones)

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat &
CD32a / FCGR2a/
FCGRIIA
Human Human CD32a transcript variant 1 Gene cDNA Clone / ORF Clone HG10374-G
CD32 / FCGRII /
FCGR2
Mouse Mouse CD32 Gene cDNA Clone / ORF Clone
MG50030-M
CD32a / FCGR2a/
FCGRIIA
Rat Rat CD32a Gene cDNA Clone / ORF Clone RG80015-M
CD32a / FCGR2a /
FCGRIIA
Rat Rat CD32a ORF Expression Clone, His-tagged RG80015-M-H
CD32a / FCGR2a /
FCGRIIA
Human Human CD32b transcript variant 3 Gene cDNA Clone / ORF Clone HG10259-M
CD32b / FCGR2b /
FCGRIIB
Human Human CD32b transcript variant 2 Gene cDNA Clone / ORF
Clone
HG10260-M
CD32b / FCGR2b /
FCGRIIB
Rat Rat CD32b Gene cDNA Clone / ORF Clone RG80018-M
CD32b / FCGR2b /
FCGRIIB
Cynomolgus Cynomolgus monkey CD32B Gene cDNA Clone / ORF Clone CG90014-M
CD32a / FCGR2a /
FCGRIIA
Cynomolgus Cynomolgus monkey FCGR2A Gene cDNA Clone
/ ORF Clone
CG90016-M

CD32 / FCGRII / Fc gamma Receptor II ELISA Pair Set (All Fc receptor ELISA Pair Set)

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat &
Human CD32b /
FCGRIIB / FCGR2b
ELISA CD32b / FCGR2B ELISA Pair Set SEK10259
Human CD32b /
FCGRIIB / FCGR2b
ELISA CD32b / FCGR2B ELISA Pair Set SEKA10259
Cynomolgus
CD32a / FCGRIIA /
FCGR2a
ELISA CD32a / Fc gamma RIIA / FCGR2A ELISA Pair Set SEK90016

CD32 / FCGRII / Fc gamma Receptor II Alternative Names

CD32, CD32A, CD32B, FcγRII, FCGR2, FCGR2A, FCGR2B, FCG2, CDw32, IGFR2, FcGR [Homo sapiens]

CD32, FcγRII, FcgRII, Fcgr2, Fcgr2a, Fcgr2b, Ly-17, Ly-m20, LyM-1, Lym-1 [Mus musculus]

CD32 / FCGRII / Fc gamma Receptor II Related Areas

Cardiovascular>>Platelet>>CD32 / Fc gamma Receptor II / FCGRII

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD32 / Fc gamma Receptor II / FCGRII

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>CD32 / Fc gamma Receptor II / FCGRII

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CD32 / Fc gamma Receptor II / FCGRII

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD32 / Fc gamma Receptor II / FCGRII

Immunology>>Fc Receptor>>CD32 / Fc gamma Receptor II / FCGRII

 

CD32 / FCGRII / Fc gamma Receptor II (Cluster of differentiation 32)

CD32 / Fc gamma Receptor II is a 40kD glycoprotein with low affinity for human IgG, which also binds mouse IgG1. CD32 / Fc gamma Receptor II protein is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. CD32 / Fc gamma Receptor II is involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells.

CD32a / FCGRIIA / Fc gamma Receptor IIA and CD32b / FCGRIIB / Fc gamma Receptor IIB

Until now two allelic forms of CD32 / Fc gamma Receptor II could be distinguished, named CD32a and CD32b. CD32a and CD32b differ in their extracellular region by only 7% of the amino acid residues. Nevertheless, both forms can be distinguished by their binding characteristics to human and mouse IgG subclasses and their differing affinities to human IgGs. CD32a leads to cell activation via the immune tyrosine based activation motifs present in its cytoplasmic domain. CD32b contributes to controlling both the threshold and the extent of immune activation by maintaining immune tolerance and preventing the emergence of autoimmune disease.

General Information for CD32a / FCGRIIA / Fc gamma Receptor IIA

 

Protein names

CD32a / FCGRIIA / Fc gamma Receptor IIA

Sequence length

317 AA

Function

Binds to the Fc region of immunoglobulins gamma.
Low affinity receptor.
By binding to IgG, CD32a initiates cellular responses against pathogens and soluble antigens.
Promotes phagocytosis of opsonized antigens

Subunit structure

Interacts with INPP5D / SHIP1 and INPPL1 / SHIP2: regulating its function.
Interacts with APCS and FGR.
Interacts with HCK  

Subcellular location: Cell membrane:Single-pass type I membrane protein
Tissue specificity

Found on monocytes, neutrophils and eosinophil platelets

Sequence similarities Contains 2 Ig-like C2-type (immunoglobulin-like) domains

General information above from UniProt

General Information for CD32b / FCGRIIB / Fc gamma Receptor IIB

 

Protein names

CD32b / FCGR IIb / Fc gamma Receptor IIB

Sequence length

310 AA

Function

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma.
Low affinity receptor.
Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor.
Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

Subunit structure

Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN

Subcellular location: Cell membrane; Single-pass type I membrane protein
Tissue specificity

CD32b is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells

Sequence similarities Contains 2 Ig-like C2-type (immunoglobulin-like) domains

General information above from UniProt

 

CD32 Related Studies

  1. Williams TE, et al. (2000) Concurrent and independent binding of Fcgamma receptors IIa and IIIb to surface-bound IgG. Biophys J. 79(4): 1867-75.
  2. Kanters D, et al. (2007) Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects. J Allergy Clin Immunol. 120(5): 1073-81.
  3. Veri MC, et al. (2007) Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization. Immunology. 121(3): 392-404.

 

 

CD32 (FCGR, Fc gamma Receptor) related areas, pathways, and other information

 

 

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