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CD31 / PECAM1 Antibody (FITC), Mouse MAb
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CD31 / PECAM1 Antibody (FITC), Mouse MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
10148-MM13-F  
YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

CD31 / PECAM1 Antibody Datasheet

  Order or Inquire for CD31 / PECAM1 Antibody product Quality antibodies Antibody production services
 

CD31 / PECAM1 Antibody Product Information

Immunogen :

Recombinant Human CD31 / PECAM1 protein (Catalog#10148-H08H)

Reagents : FITC-conjugated mouse monoclonal antibody

Clone ID :

13

Ig Type :

Mouse IgG1

Concentration :

10 μl/Test, 0.1 mg/ml

Formulation : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation :

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD31 / PECAM1 (rh CD31 / PECAM1; Catalog#10148-H08H; EAW94208.1; Met 1-Lys 601) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

CD31 / PECAM1 Antibody Usage Guide

Specificity :

Human CD31 / PECAM1

Flow Cytometry :
CD31 / PECAM1 Flow Cytometry

Profile of anti-CD31 reactivity on HUVEC cells analyzed by flow cytometry.

Flow cytometry was performed on a BD FACSCalibur flow cytometry system

Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.

Storage : This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

CD31 / PECAM1 Antibody Related Products & Topics

CD31 / PECAM1 Antibody Related Areas:

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD31

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>CD31

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>CD31

Cancer>>Cancer Stem Cell (CSC)>>CD31

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD31

Cancer>>Cancer Biomarkers>>CD31

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD31

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM)>>CD31

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD31

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD31

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD31/PECAM-1 Human CD31/PECAM1/Fc Protein, Recombinant 10148-H02H
CD31/PECAM-1 Human CD31/PECAM1 Protein, Recombinant 10148-H08H
CD31/PECAM-1 Human CD31/PECAM1 Protein, Recombinant 10148-HCCH
CD31/PECAM-1 Mouse CD31/PECAM1 Protein, Recombinant 50408-M08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD31/PECAM-1
WB, IHC-P CD31 / PECAM1 Antibody (Mouse Monoclonal Antibody) 10148-MM01
Human
CD31/PECAM-1
ELISA, IHC Mouse Monoclonal Antibody 10148-MM02
Human
CD31/PECAM-1
FCM CD31 / PECAM1 Antibody ( FITC ) 10148-MM02-F
Human
CD31/PECAM-1
IHC-P CD31 / PECAM1 Antibody 10148-MM13
Human
CD31/PECAM-1
FCM CD31 / PECAM1 Antibody ( FITC ) 10148-MM13-F
Human
CD31/PECAM-1
WB, ELISA CD31 / PECAM1 Antibody 10148-RP01
Human
CD31/PECAM-1
WB, ELISA, IHC-P CD31 / PECAM1 Antibody (Antigen Affinity Purified) 10148-RP02

CD31 / PECAM1 Antibody Background

(PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets, and is the only known member of the CAM family on platelets. PECAM-1 has six Ig-homology domains that share sequence similarity with cellular adhesion molecules within the extracellular region, and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Accordingly, CD31acts as a signaling molecule when appropriately engaged and creates docking sites for the Src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1 and SHP-2. PECAM-1 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up-regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.

References

  1. Newman, P.J. et al., 1990, Science. 247:1219-1222.
  2. Sun, J. et al., 1996, J. Biol. Chem. 271: 18561-18570.
  3. Newton-Nash, D.K. and Neman, P.J. et al., 1999, J. Immunol. 163: 682-688.
  4. Rui, Y.X. et al., 2007, J. Immunol. 179: 7344-7351.
  5. Woodfin, A. et al., 2007, Arterioscler. Thromb. Vasc. Biol. 27: 2514-2523.
 

 

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