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>CD31 Protein & Antibody (PECAM-1)
CD31 Protein & Antibody (PECAM-1)
CD31 / PECAM-1 Related Areas
CD31 Alternative Names
PECAM-1, TGFB, TGFbeta, CED, DPD1, LAP [Homo sapiens]
CD31, Tgfb1, TGFbeta1, Tgfb, Tgfb-1 [Mus musculus]
CD31 / PECAM-1 Background
The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets. CD31 protein is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies. CD31 plays a key role in removing aged neutrophils and tissue regeneration. CD31 protein mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development.
CD31 / PECAM-1 in angiogenesis. The adhesive interactions of endothelial cells with each other and the adhesion receptors that mediate these interactions are probably of fundamental importance to the process of angiogenesis. It has been studied about the effect of inhibiting the function of the endothelial cell-cell adhesion molecule, CD31 / PECAM-1, in rat and murine models of angiogenesis. A polyclonal antibody to human CD31 / PECAM-1, which cross-reacts with rat CD31 / PECAM-1, was found to block in vitro tube formation by rat capillary endothelial cells and cytokine-induced rat corneal neovascularization. In mice, two monoclonal antibodies against murine CD31 / PECAM-1 prevented vessel growth into subcutaneously implanted gels supplemented with basic fibroblast growth factor (bFGF). Taken together these findings provide evidence that CD31 / PECAM-1 is involved in angiogenesis and suggest that the interactions of endothelial cell-cell adhesion molecules are important in the formation of new vessels.
CD31 / PECAM-1 Related Studies
- Deaglio S, et al. (2000) CD38/CD31, a receptor/ligand system ruling adhesion and signaling in human leukocytes. Chem Immunol. 75: 99-120.
- Kohler S, et al. (2009) Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood. 113(4): 769-74.
- H. M. DeLisser, et al. (1997) Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol. 151(3): 671–677.