CD302 / CLEC13A Protein

Cluster of Differentiation 302 / C-type lectin domain family 13, member A

CD302 / CLEC13A Products

CD302 / CLEC13A Protein, Recombinant

Molecule	Species	Description	Cat. No
CD302/CLEC13A	Mouse	CD302/CLEC13A Protein, Recombinant	50706-M02H
CD302/CLEC13A	Mouse	CD302/CLEC13A Protein, Recombinant	50706-M08H

CD302 / CLEC13A cDNA Clone

Molecule	Species	Description	Cat. No
CD302/CLEC13A	Mouse	Mouse CD302/CLEC13A cDNA Clone / ORF Clone	MG50706-M
CD302/CLEC13A	Rat	CD302 cDNA Clone / ORF Clone	RG80414-G

CD302 / CLEC13A Related Areas

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD302/CLEC13A

Immunology>>Adhesion Molecule>>Lectin>>CD302/CLEC13A

CD302 / CLEC13A Alternative Names

CD302, CLEC13A, DCL1, DCL-1, BIMLEC, CLEC13A, FLJ43091, KIAA0022, MGC22301 [Homo sapiens]

Cd302, CLEC13A, RP23-10L17.2, 1110055L24Rik, AI159627 [Mus musculus]

CD302 / CLEC13A Background

CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function.

CD302 / CLEC13A Related Studies

1. Kato M, et al. (2007) The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. J Immunol. 179(9): 6052-63.
2. Skinnider BF, et al. (2002) The role of cytokines in classical Hodgkin lymphoma. Blood. 99(12): 4283-97.