Anti-CD300A Antibody

Cat: 12449-RP02
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Anti-CD300A Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD300A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD300A
Immunogen
Recombinant Human CD300A protein (Catalog#12449-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD300A (rh CD300A; Catalog#12449-H08H; Q9UGN4-1; Met 1-Gln 178). CD300A specific IgG was purified by Human CD300A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD300A Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD300A Antibody Alternative Names
Anti-CLM-8 Antibody;Anti-CMRF-35-H9 Antibody;Anti-CMRF-35H Antibody;Anti-CMRF35-H Antibody;Anti-CMRF35-H9 Antibody;Anti-CMRF35H Antibody;Anti-CMRF35H9 Antibody;Anti-IGSF12 Antibody;Anti-IRC1 Antibody;Anti-IRC1/IRC2 Antibody;Anti-IRC2 Antibody;Anti-IRp60 Antibody
CD300A Background Information

CMRF35-like molecule 8, also known as CD300 antigen-like family member A, CMRF35-H9, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, CD300a and CMRF35H, is a single-pass type I membrane protein which belongs to the CD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating ( CD300b, CD300e ) and inhibitory members ( CD300a, CD300f ), as well as molecules presenting a negative charge within their transmembrane domain ( CD300c, CD300d ).  CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.It contains one Ig-like V-type ( immunoglobulin-like ) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).

Full Name
CD300a molecule
References
  • Bachelet,I. et al., 2005, J. Immunol. 175:7989-7995.
  • Bachelet,I. et al., 2008, J Immunol. 180 (9):6064-9.
  • Ju,X. et al., 2008, Blood. 112 (4):1184-94.
  • Martínez-Barriocanal,A. et al., 2010, J Biol Chem. 285 (53):41781-94.
  • Lankry,D. et al., 2010, J Immunol. 185 (5):2877-86.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD300A Antibody Mouse Monoclonal FCM 12449-MM01
    Anti-CD300A Antibody Rabbit Polyclonal ELISA 12449-RP01
    Anti-CD300A Antibody (FITC) Mouse Monoclonal FCM 12449-MM01-F
    Anti-CD300A Antibody (APC) Mouse Monoclonal FCM 12449-MM01-A
    Anti-CD300A Antibody (PE) Mouse Monoclonal FCM 12449-MM01-P
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