Anti-CD300A Antibody

Cat: 12449-RP02
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All CD300A Reagents
Anti-CD300A Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD300A Antibody
Validated applications
Species reactivity
Reacts with: Human
Human CD300A
Recombinant Human CD300A protein (Catalog#12449-H08H)
Produced in rabbits immunized with purified, recombinant Human CD300A (rh CD300A; Catalog#12449-H08H; Q9UGN4-1; Met 1-Gln 178). CD300A specific IgG was purified by Human CD300A affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD300A Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD300A Antibody Alternative Names
Anti-CLM-8 Antibody;Anti-CMRF-35-H9 Antibody;Anti-CMRF-35H Antibody;Anti-CMRF35-H Antibody;Anti-CMRF35-H9 Antibody;Anti-CMRF35H Antibody;Anti-CMRF35H9 Antibody;Anti-IGSF12 Antibody;Anti-IRC1 Antibody;Anti-IRC1/IRC2 Antibody;Anti-IRC2 Antibody;Anti-IRp60 Antibody
CD300A Background Information

CMRF35-like molecule 8, also known as CD300 antigen-like family member A, CMRF35-H9, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, CD300a and CMRF35H, is a single-pass type I membrane protein which belongs to the CD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating ( CD300b, CD300e ) and inhibitory members ( CD300a, CD300f ), as well as molecules presenting a negative charge within their transmembrane domain ( CD300c, CD300d ).  CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.It contains one Ig-like V-type ( immunoglobulin-like ) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).

Full Name
CD300a molecule
  • Bachelet,I. et al., 2005, J. Immunol. 175:7989-7995.
  • Bachelet,I. et al., 2008, J Immunol. 180 (9):6064-9.
  • Ju,X. et al., 2008, Blood. 112 (4):1184-94.
  • Martínez-Barriocanal,A. et al., 2010, J Biol Chem. 285 (53):41781-94.
  • Lankry,D. et al., 2010, J Immunol. 185 (5):2877-86.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD300A Antibody Mouse Monoclonal FCM 12449-MM01
    Anti-CD300A Antibody Rabbit Polyclonal ELISA 12449-RP01
    Anti-CD300A Antibody (FITC) Mouse Monoclonal FCM 12449-MM01-F
    Anti-CD300A Antibody (APC) Mouse Monoclonal FCM 12449-MM01-A
    Anti-CD300A Antibody (PE) Mouse Monoclonal FCM 12449-MM01-P
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