CD30 / TNFRSF8: CD30 / TNFRSF8 Protein | CD30 / TNFRSF8 Antibody

CD30 / TNFRSF8 Gene family

CD30 / TNFRSF8 Background

CD3, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD3 protein is expressed by activated, but not resting, T and B cells. CD3 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD3 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD3 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD3 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

Reference for CD30 / TNFRSF8

  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.

CD30 / TNFRSF8 Protein

CD30 / TNFRSF8 protein function

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

CD30 / TNFRSF8 protein sequence

This sequence information is just for reference only.From Uniport

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CD30 / TNFRSF8 Antibody

There are 15 CD30 / TNFRSF8 antibodies which are validated in multiple tissues with various applications, including IHC-P, WB, ELISA, FCM, ELISA(Cap), ELISA(Det). There are 2 CD30 / TNFRSF8 antibody for IHC-P, 2 CD30 / TNFRSF8 antibody for WB, 6 CD30 / TNFRSF8 antibody for ELISA, 6 CD30 / TNFRSF8 antibody for FCM, 1 CD30 / TNFRSF8 antibody for ELISA(Cap), 1 CD30 / TNFRSF8 antibody for ELISA(Det). Among all these CD30 / TNFRSF8 antibodies, there are 5 anti-CD30 / TNFRSF8 rabbit polyclonal antibodies , 7 anti-CD30 / TNFRSF8 mouse monoclonal antibodies , 3 anti-CD30 / TNFRSF8 rabbit monoclonal antibodies . All the CD30 / TNFRSF8 anbodies are produced in house and all are in stock. CD30 / TNFRSF8 antibody customerized service is available.

CD30 / TNFRSF8 Gene

TNFRSF8 gene / cDNA is a protein-coding gene which located on 1p36.22. The TNFRSF8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.178 organisms have orthologs with human gene TNFRSF8.