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CD30/TNFRSF8 Protein, Antibody, ELISA Kit, cDNA Clone

CD30/TNFRSF8 Related Areas

CD30/TNFRSF8 Related Pathways

CD30/TNFRSF8 Related Product

CD30/TNFRSF8 Summary & Protein Information

CD30/TNFRSF8 Related Information

CD30/TNFRSF8 Background

Gene Summary: The protein encoded by TNFRSF8 gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of TNFRSF8 gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein.
Isoform Short: Cytoplasm.
Post-translational: Phosphorylated on serine and tyrosine residues.
Sequence similarity: Contains 6 TNFR-Cys repeats.
General information above from UniProt

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

CD30/TNFRSF8 Alternative Name

CD30,D1S166E,Ki-1,TNFRSF8, [human]
Ki,Cd30,D1S166E,Ki-1,RP23-306F22.1,Tnfrsf8, [mouse]

CD30/TNFRSF8 Related Studies

  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.