Anti-CD30 Antibody

Cat: 10777-RP02
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Anti-CD30 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD30 Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CD30
Immunogen
Recombinant Human CD30 / TNFRSF8 protein (Catalog#10777-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD30 / TNFRSF8 (rh CD30 / TNFRSF8; Catalog#10777-H08H; NP_001234.2; Met 1-Lys 379). CD30 / TNFRSF8 specific IgG was purified by Human CD30 / TNFRSF8 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD30 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  
IHC-P 1:2000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD30 Antibody (Rabbit Polyclonal antibody) Images
Human CD30/TNFRSF8 Immunohistochemistry(IHC) 3505
Immunochemical staining of human TNFRSF8 in human hodgkin lymphoma with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections.
Human CD30/TNFRSF8 Western blot (WB) 6617

Anti-TNFRSF8 rabbit polyclonal antibody at 1:500 dilution.

Lane A: A431 Membrane Lysate

Lysates/proteins at 30 ug per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:64 kDa

Observed band size:60 kDa

(We are unsure as to the identity of these extra bands.)

Anti-CD30 Antibody Alternative Names
Anti-CD30 Antibody;Anti-D1S166E Antibody;Anti-Ki-1 Antibody
CD30 Background Information

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 8
Research Areas
References
  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD30 Antibody Rabbit Polyclonal IHC-P 101923-T08
    Anti-CD30 Antibody (PE) Rabbit Monoclonal FCM 10777-R002-P
    Anti-CD30 Antibody Mouse Monoclonal ELISA(Cap) 10777-MM08
    Anti-CD30 Antibody Mouse Monoclonal ELISA 10777-MM01
    Anti-CD30 Antibody (APC) Mouse Monoclonal FCM 10777-MM05-A
    Anti-CD30 Antibody (PE) Mouse Monoclonal FCM 10777-MM05-P
    Anti-CD30 Antibody Mouse Monoclonal ELISA 10777-MM06
    Anti-CD30 Antibody (APC) Rabbit Monoclonal FCM 10777-R002-A
    Anti-CD30 Antibody Rabbit Polyclonal ELISA 10777-RP01
    Anti-CD30 Antibody (FITC) Mouse Monoclonal FCM 10777-MM05-F
    Anti-CD30 Antibody Mouse Monoclonal FCM 10777-MM05
    Anti-CD30 Antibody Rabbit Polyclonal ELISA 10777-T16
    Anti-CD30 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10777-R015
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