CD28 Protein & Antibody

Cluster of Differentiation 28

CD28 Products

CD28 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD28	Human	CD28/Fc Protein, Recombinant	11524-H02H
CD28	Human	CD28 Protein, Recombinant	11524-H08H
CD28	Mouse	CD28/Fc Protein, Recombinant	50103-M03H
CD28	Mouse	CD28 Protein, Recombinant	50103-M08H

11524-H02H: Immobilized human CD86 at 20 µg/ml (100 µl/well) can bind human CD28 Fc chimera with a linear ranger of 32-800 ng/ml. Measured by its binding ability in a functional ELISA.

11524-H08H:

1. Measured by its ability to bind human CD80 in a functional Elisa.

2. Immobilized human CD28 at 20 µg/ml (100 µl/well) can bind mouse CD86 with a linear ranger of 6.4-160 ng/ml. Measured by its ability to bind human CD86 in a functional Elisa.

50103-M03H:

1. Immobilized mouse CD86 at 20 µg/ml (100 µl/well) can bind mouse CD28 Fc Chimera with a linear ranger of 6.4-800 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized rat CD86 at 2 µg/ml (100 µl/well) can bind mouse CD28 Fc Chimera with a linear ranger of 6.4-160 ng/ml. Measured by its binding ability in a functional ELISA.

CD28 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD28	WB, ELISA	CD28 Antibody	11524-RP01
Human CD28	WB, ELISA	CD28 Antibody (Antigen Affinity Purified)	11524-RP02
Human CD28	WB	CD28 Antibody	11524-MM02
Human CD28	ELISA	CD28 Antibody	11524-MM06
Mouse CD28	WB, ELISA	CD28 Antibody (Antigen Affinity Purified)	50103-RP02

CD28 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD28	Human	Homo sapiens CD28 cDNA Clone	HG11524-M
CD28	Mouse	Mus musculus CD28 cDNA Clone	MG50103-M
CD28	Rat	Rat CD28 cDNA Clone / ORF Clone	RG80302-G
CD28	Cynomolgus	Cynomolgus monkey CD28 Gene cDNA Clone / ORF Clone	CG90182-G

CD28 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD28

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Antigen Recognition>>CD28

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD28

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Co-stimulatory Molecules>>CD28

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD28

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Antigen Recognition>>CD28

CD28 Alternative Names

CD28, MGC138290, Tp44 [Homo sapiens]

Cd28, CH29-189K17.3 [Mus musculus]

CD28 Background

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

CD28 Related Studies

Keir ME, et al. (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-43.
Sansom DM, et al. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 212: 131-48.
Bjørgo E, et al. (2010) Novel mechanism of signaling by CD28. Immunol Lett. 129(1): 1-6.

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