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CD28Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
  • Slide 1
11524-H02H-100
11524-H02H-200
100 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
11524-HCCH-100
11524-HCCH-200
100 µg 
200 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50103-M03H-100
50103-M03H-200
100 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
50103-M08H-100
50103-M08H-200
100 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
80302-R02H-50
80302-R02H-200
50 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
80302-R08H-50
80302-R08H-200
50 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
90182-C02H-50
90182-C02H-200
50 µg 
200 µg 
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CD28 Related Pathways

CD28 Related Protein, Antibody, cDNA Gene, and ELISA Kits

CD28 Related Protein, Antibody, cDNA Gene, and ELISA Kits

Featured Reagent Products

CD28 Summary & Protein Information

CD28 Background

Gene Summary: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
General information above from NCBI
Subunit structure: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

CD28 Alternative Name

Tp44, [homo-sapiens]
CD28,MGC138290,Tp44, [human]
Cd28,CH29-189K17.3, [mouse]

CD28 Related Studies

  • Keir ME, et al. (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-43.
  • Sansom DM, et al. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 212: 131-48.
  • Bjrgo E, et al. (2010) Novel mechanism of signaling by CD28. Immunol Lett. 129(1): 1-6.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"