Anti-CD28 Antibody

Cat: 50103-RP02
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Anti-CD28 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD28 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD28
Immunogen
Recombinant Mouse CD28 protein (Catalog#50103-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CD28 (rM CD28; Catalog#50103-M08H; NP_031668.3; Met 1-Lys 149). CD28 specific IgG was purified by Mouse CD28 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD28 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:1000-1:4000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD28 Antibody (Rabbit Polyclonal antibody) Images
Mouse CD28/TP44 Immunohistochemistry(IHC) 3352
Immunochemical staining of mouse CD28 in mouse spleen with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
CD28 Background Information

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD28 molecule
References
  • Keir ME, et al. (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-43.
  • Sansom DM, et al. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 212: 131-48.
  • Bjrgo E, et al. (2010) Novel mechanism of signaling by CD28. Immunol Lett. 129(1): 1-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD28 Antibody Mouse Monoclonal ELISA 80302-MM04
    Anti-CD28 Antibody Rabbit Polyclonal ELISA 80302-T16
    Anti-CD28 Antibody Rabbit Polyclonal WB,ELISA 50103-T48
    Anti-CD28 Antibody Rabbit Polyclonal ELISA 50103-RP01
    Anti-CD28 Antibody Rabbit Monoclonal ELISA,FCM 11524-R007
    Anti-CD28 Antibody (FITC) Rabbit Monoclonal FCM 11524-R007-F
    Anti-CD28 Antibody FCM,Func/A 11524-H001
    Anti-CD28 Antibody (PerCP) Rabbit Monoclonal FCM 11524-R007-C
    Anti-CD28 Antibody Rabbit Polyclonal ELISA 11524-RP01
    Anti-CD28 Antibody Rabbit Polyclonal ELISA 11524-RP02
    Anti-CD28 Antibody Mouse Monoclonal ELISA(Det) 11524-MM04
    Anti-CD28 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 11524-MM06
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