Anti-CD27 Antibody (FITC)

Cat: 50110-R012-F
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Anti-CD27 Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD27 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD27
Immunogen
Recombinant Mouse CD27 protein (Catalog#50110-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27 / TNFRSF7 (rM CD27 / TNFRSF7; Catalog#50110-M08H; NP_001028298.1; Met 1-Arg 182) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Rabbit IgG Clone #012
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD27 Antibody (FITC) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD27 Antibody (FITC) (Rabbit Monoclonal antibody) Images
Mouse CD27/TNFRSF7 Flow Cytometry (FC) 5446
Expression of CD27 on mouse splenocytes. BABL/c splenocytes were stained simultaneously with FITC-conjugated mAb R012 and PE-conjugated anti-mouse CD3 mAb (BD Pharmingen™Cat. No. 553064).
Anti-CD27 Antibody (FITC) Alternative Names
Anti-S152 Antibody;Anti-Tnfrsf7 Antibody;Anti-Tp55 Antibody
CD27 Background Information

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD27 molecule
Research Areas
References
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD27 Antibody Rabbit Monoclonal IHC-P 50110-R618
    Anti-CD27 Antibody Rabbit Monoclonal ELISA 50110-R133
    Anti-CD27 Antibody Rabbit Monoclonal ELISA 50110-R034
    Anti-CD27 Antibody Rabbit Polyclonal ELISA,IHC-P 50110-RP02
    Anti-CD27 Antibody (PE) Rabbit Monoclonal FCM 50110-R012-P
    Anti-CD27 Antibody (APC) Rabbit Monoclonal FCM 50110-R012-A
    Anti-CD27 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50110-R012
    Anti-CD27 Antibody Rabbit Polyclonal ELISA 50110-RP01
    Anti-CD27 Antibody (PerCP) Rabbit Monoclonal FCM 50110-R012-C
    Anti-CD27 Antibody Rabbit Monoclonal WB,ELISA 10039-R150
    Anti-CD27 Antibody (APC) Rabbit Monoclonal FCM 10039-R023-A
    Anti-CD27 Antibody (PerCP) Rabbit Monoclonal FCM 10039-R025-C
    Anti-CD27 Antibody (APC) Rabbit Monoclonal FCM 10039-R025-A
    Anti-CD27 Antibody (PerCP) Rabbit Monoclonal FCM 10039-R023-C
    Anti-CD27 Antibody Rabbit Monoclonal FCM 10039-R025
    Anti-CD27 Antibody Rabbit Polyclonal ELISA,IHC-P 10039-T24
    Anti-CD27 Antibody (FITC) Mouse Monoclonal FCM 10039-MM09-F
    Anti-CD27 Antibody (FITC) Rabbit Monoclonal FCM 10039-R025-F
    Anti-CD27 Antibody Rabbit Polyclonal ELISA 10039-RP01
    Anti-CD27 Antibody Rabbit Monoclonal ELISA 10039-R036
    Anti-CD27 Antibody (PE) Rabbit Monoclonal FCM 10039-R025-P
    Anti-CD27 Antibody Mouse Monoclonal FCM 10039-MM09
    Anti-CD27 Antibody (PerCP) Mouse Monoclonal FCM 10039-MM09-C
    Anti-CD27 Antibody (FITC) Rabbit Monoclonal FCM 10039-R023-F
    Anti-CD27 Antibody (PE) Rabbit Monoclonal FCM 10039-R023-P
    Anti-CD27 Antibody (PE) Mouse Monoclonal FCM 10039-MM09-P
    Anti-CD27 Antibody (APC) Mouse Monoclonal FCM 10039-MM09-A
    Anti-CD27 Antibody Mouse Monoclonal ELISA 10039-MM08
    Anti-CD27 Antibody Rabbit Monoclonal FCM 10039-R023
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