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CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb

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Mouse CD27/TNFRSF7 Antibody Product Information
Immunogen:Recombinant Mouse CD27 protein (Catalog#50110-M08H)
Clone ID:012
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27 / TNFRSF7 (rM CD27 / TNFRSF7; Catalog#50110-M08H; NP_001028298.1; Met 1-Arg 182) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Mouse CD27/TNFRSF7 Antibody Usage Guide
Specificity:Mouse CD27 / TNFRSF7
Has cross-reactivity in ELISA with
Human CD27
Human BAFF
No cross-reactivity in ELISA with
Human TNFRSF8
Human CD40
Human DR6
Human TNFRSF10D
Mouse HVEM
Mouse FAS
Mouse TNFRSF10b
Human 4-1BB
Human TNFRI
Human TNFRII
Human RELT
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Mouse CD27/TNFRSF7 Antibody FC Application Image
CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Caption:
Expression of CD27 on mouse splenocytes. BABL/c splenocytes were stained simultaneously with FITC-conjugated mAb R012 and PE-conjugated anti-mouse CD3 mAb (BD Pharmingen™Cat. No. 553064).
Other CD27/TNFRSF7 Antibody Products
CD27/TNFRSF7 Background

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Mouse CD27/TNFRSF7 References
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"