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CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb

  • Human CD27/TNFRSF7 Flow Cytometry (FC) 5421
  • CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb, Flow cytometric
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Human CD27/TNFRSF7 Antibody Product Information
Immunogen:Recombinant Human CD27 / TNFRSF7 protein (Catalog#10039-H03H)
Clone ID:023
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD27 (rh CD27; Catalog#10039-H03H; Met 1-Ile 192; NP_001233.1) and conjugated with FITC under optimum conditions, the unreacted FITC was removed .
Human CD27/TNFRSF7 Antibody FC Application Image
CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Flow cytometric analysis of anti-human CD27 on human whole blood lymphocytes. Human lymphocytes were stained with anti human CD27-R023 (solid line) or rabbit IgG isotype control (dashed line). left panel: Catalog#10039-R023F, FITC Rabbit anti-Human CD27 antibody right panel: Catalog#10039-R023-P, PE Rabbit anti-Human CD27 antibody
Other CD27/TNFRSF7 Antibody Products
CD27/TNFRSF7 Background

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human CD27/TNFRSF7 References
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
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