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CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb

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Human CD27/TNFRSF7 Antibody Product Information
Immunogen:Recombinant Human CD27 / TNFRSF7 protein (Catalog#10039-H03H)
Clone ID:023
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD27 (rh CD27; Catalog#10039-H03H; Met 1-Ile 192; NP_001233.1) and conjugated with FITC under optimum conditions, the unreacted FITC was removed .
Human CD27/TNFRSF7 Antibody Usage Guide
Specificity:Human CD27 / TNFRSF7
Has cross-reactivity in ELISA with
Mouse CD27
No cross-reactivity in ELISA with
Human TNFRSF8/CD30
Human 4-1BB
Human CD40
Human DR6
Human FAS
Human HVEM/TNFRSF14
Human TNFRI
Human TNFRII
Human BAFF
Human RELT
Mouse HVEM
Mouse FAS
Rat FAS
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human CD27/TNFRSF7 Antibody FC Application Image
[Click to enlarge image]
Caption:
Flow cytometric analysis of anti-human CD27 on human whole blood lymphocytes. Human lymphocytes were stained with anti human CD27-R023 (solid line) or rabbit IgG isotype control (dashed line). left panel: Catalog#10039-R023F, FITC Rabbit anti-Human CD27 antibody right panel: Catalog#10039-R023-P, PE Rabbit anti-Human CD27 antibody
CD27 / TNFRSF7 Antibody (FITC), Rabbit MAb, Flow cytometric
Other CD27/TNFRSF7 Antibody Products
CD27 Background

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Human CD27 References
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
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    Catalog: 10039-R023F-50
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"