CD27 Protein & Antibody (TNFRSF7)

Cluster of Differentiation 27 (Tumor Necrosis Factor Receptor Superfamily Member 7)

CD27 Products

CD27 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD27	Human	CD27/Fc Protein, Recombinant	10039-H03H
CD27	Mouse	CD27/Fc Protein, Recombinant	50110-M03H
CD27	Mouse	CD27 Protein, Recombinant	50110-M08H

10039-H03H: Immobilized recombinant human CD27 at 2 µg/mL (100 µl/well) can bind biotinylated human CD70 with a linear range of 0.39-12.5 ng/ml. Measured by its ability to bind with recombinant human CD70.

50110-M03H: Immobilized recombinant mouse CD27 at 2 µg/mL (100 µl/well) can bind biotinylated human CD70 with a linear range of 0.39-12.5 ng/ml. Measured by its binding ability in a functional ELISA.

50110-M08H: Immobilized recombinant mouse CD27 at 2 µg/mL (100 µl/well) can bind biotinylated human CD70 with a linear range of 78-1250 pg/ml. Measured by its binding ability in a functional ELISA.

CD27 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD27	WB, ELISA	CD27 Antibody	10039-MM08
Human CD27	WB, ELISA	CD27 / TNFRSF7 Antibody ( FITC )	10039-R023F
Human CD27	WB, ELISA	CD27 / TNFRSF7 Antibody ( PE )	10039-R023-P
Human CD27	WB, ELISA	CD27 / TNFRSF7 Antibody ( FITC )	10039-R025F
Human CD27	WB, ELISA	CD27 Antibody	10039-R036
Mouse CD27	WB, ELISA	CD27 Antibody, Rabbit PAb	50110-RP01
Mouse CD27	WB, ELISA	CD27 Antibody, Rabbit PAb (Antigen Affinity Purified)	50110-RP02
Mouse CD27	FCM	CD27 / TNFRSF7 Antibody ( FITC )	50110-R012-F
Mouse CD27	WB, ELISA	CD27 Antibody	50110-R034
Mouse CD27	WB ELISA	CD27 Antibody	50110-R133

CD27 cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD27	Human	CD27 / TNFRSF7 DNA ORF Clone	HG10039-M
CD27	Mouse	CD27 / TNFRSF7 cDNA Clone / ORF Clone	MG50110-M
CD27	Rat	CD27 cDNA Clone / ORF Clone	RG80158-G
CD27	Cynomolgus	CD27 cDNA Clone / ORF Clone	KG90049-G

CD27 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD27/TNFRSF7

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD27/TNFRSF7

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD27/TNFRSF7

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD27/TNFRSF7

CD27 Alternative Names

CD27, MGC20393, S152, T14, TNFRSF7, Tp55 [Homo sapiens]

Cd27, S152, Tnfrsf7, Tp55 [Mus musculus]

CD27 Background

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

CD27 Related Studies

Dörner T, et al. (2004) Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenström's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.

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