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CD27/TNFRSF7  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
10039-H03H-200
10039-H03H-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
10039-H31H-200
10039-H31H-100
200 µg 
100 µg 
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Description: Active  
Expression host: Baculovirus-Insect Cells  
  • Slide 1
10039-H08B1-200
10039-H08B1-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50110-M03H-50
50110-M03H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50110-M08H-50
50110-M08H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
90049-C02H-50
90049-C02H-100
50 µg 
100 µg 
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CD27/TNFRSF7 Related Area

CD27/TNFRSF7 Related Pathways

CD27/TNFRSF7 Related Protein, Antibody, cDNA Gene, and ELISA Kits

CD27/TNFRSF7 Summary & Protein Information

CD27/TNFRSF7 Background

Gene Summary: The protein encoded by CD27 gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subunit structure: Homodimer. Interacts with SIVA1 and TRAF2.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Found in most T-lymphocytes.
Post-translational: Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.
Involvement in disease: Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 3 TNFR-Cys repeats.
General information above from UniProt

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Immune Checkpoint
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Immune Checkpoint Proteins
Immune Checkpoint TargetsCo-stimulatory Immune Checkpoint Targets

CD27/TNFRSF7 Alternative Name

CD27/TNFRSF7 Related Studies

  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
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