Anti-CD27 Antibody

Cat: 50110-R034
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Anti-CD27 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD27 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD27
No cross-reactivity in ELISA with Human CD27 Human TNFRSF8 Human CD40 Human DR6 Human TNFRSF10D Mouse HVEM Mouse FAS Mouse TNFRSF10b Human 4-1BB Human TNFRI Human BAFF Human TNFRII Human RELT
Immunogen
Recombinant Mouse CD27 protein (Catalog#50110-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27 (rM CD27; Catalog#50110-M08H; NP_001028298.1; Met 1-Arg 182).
Source
Monoclonal Rabbit IgG Clone #034
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD27 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD27 Antibody Alternative Names
Anti-S152 Antibody;Anti-Tnfrsf7 Antibody;Anti-Tp55 Antibody
CD27 Background Information

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD27 molecule
Research Areas
References
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD27 Antibody (FITC) Rabbit Monoclonal FCM 50110-R012-F
    Anti-CD27 Antibody Rabbit Monoclonal IHC-P 50110-R618
    Anti-CD27 Antibody Rabbit Monoclonal ELISA 50110-R133
    Anti-CD27 Antibody Rabbit Polyclonal ELISA,IHC-P 50110-RP02
    Anti-CD27 Antibody (PE) Rabbit Monoclonal FCM 50110-R012-P
    Anti-CD27 Antibody (APC) Rabbit Monoclonal FCM 50110-R012-A
    Anti-CD27 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50110-R012
    Anti-CD27 Antibody Rabbit Polyclonal ELISA 50110-RP01
    Anti-CD27 Antibody (PerCP) Rabbit Monoclonal FCM 50110-R012-C
    Anti-CD27 Antibody Rabbit Monoclonal WB,ELISA 10039-R150
    Anti-CD27 Antibody (APC) Rabbit Monoclonal FCM 10039-R023-A
    Anti-CD27 Antibody (PerCP) Rabbit Monoclonal FCM 10039-R025-C
    Anti-CD27 Antibody (APC) Rabbit Monoclonal FCM 10039-R025-A
    Anti-CD27 Antibody (PerCP) Rabbit Monoclonal FCM 10039-R023-C
    Anti-CD27 Antibody Rabbit Monoclonal FCM 10039-R025
    Anti-CD27 Antibody Rabbit Polyclonal ELISA,IHC-P 10039-T24
    Anti-CD27 Antibody (FITC) Mouse Monoclonal FCM 10039-MM09-F
    Anti-CD27 Antibody (FITC) Rabbit Monoclonal FCM 10039-R025-F
    Anti-CD27 Antibody Rabbit Polyclonal ELISA 10039-RP01
    Anti-CD27 Antibody Rabbit Monoclonal ELISA 10039-R036
    Anti-CD27 Antibody (PE) Rabbit Monoclonal FCM 10039-R025-P
    Anti-CD27 Antibody Mouse Monoclonal FCM 10039-MM09
    Anti-CD27 Antibody (PerCP) Mouse Monoclonal FCM 10039-MM09-C
    Anti-CD27 Antibody (FITC) Rabbit Monoclonal FCM 10039-R023-F
    Anti-CD27 Antibody (PE) Rabbit Monoclonal FCM 10039-R023-P
    Anti-CD27 Antibody (PE) Mouse Monoclonal FCM 10039-MM09-P
    Anti-CD27 Antibody (APC) Mouse Monoclonal FCM 10039-MM09-A
    Anti-CD27 Antibody Mouse Monoclonal ELISA 10039-MM08
    Anti-CD27 Antibody Rabbit Monoclonal FCM 10039-R023
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