CD25 Protein & Antibody (IL-2RA, IL-2R)

Cluster of Differentiation 25 (Interleukin 2 Receptor alpha)

CD25 Products

CD25 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD25/IL-2RA	Human	CD25/IL-2RA/Fc Protein, Recombinant	10165-H02H
CD25/IL-2RA	Human	CD25/IL-2RA Protein, Recombinant	10165-H08H
CD25/IL-2RA	Mouse	CD25/IL-2RA Protein, Recombinant	50292-M08H

CD25 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD25/IL-2RA	WB, ELISA	Rabbit Polyclonal Antibody	10165-RP01
Human CD25/IL-2RA	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10165-RP02
Mouse CD25/IL-2RA	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50292-RP02

CD25 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD25/IL-2RA	Human	Homo sapiens CD25/IL-2RA cDNA Clone(NM_000417.1)	HG10165-M
CD25/IL-2RA	Human	Human CD25 / IL2Rα ORF Expression Clone, His-tagged	HG10165-M-H
CD25/IL-2RA	Human	Human CD25 / IL2Rα ORF Expression Clone, untagged	HG10165-M-N
CD25/IL-2RA	Mouse	Mus musculus CD25/IL-2RA cDNA Clone	MG50292-M
CD25/IL-2RA	Rat	Rat CD25/IL-2RA cDNA Clone / ORF Clone	RG80074-M
CD25/IL-2RA	Cynomolgus	Cynomolgus monkey IL2RA Gene cDNA Clone / ORF Clone	CG90265-G

CD25 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD25/IL-2RA

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD25/IL-2RA

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD25/IL-2RA

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD25/IL-2RA

CD25 Alternative Names

CD25, IL2RA, IL2R, RP11-536K7.1, IDDM10, TCGFR [Homo sapiens]

CD25, Il2ra, Il2r, Ly-43, MGC130561 [Mus musculus]

CD25 Background

CD25 (alpha-chain of IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development is associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of sIL-2Ralpha. In most haematological malignancies, including different types of leukaemias and lymphomas, sIL-2Ralpha has been found to be released directly from the surface of neoplastic cells thus reflecting the tumour bulk, turnover and activity. Several studies have proved that not only lymphoid cancer cells, but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, oesophagus and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.

CD25 Related Studies

Driesen J, et al. (2008) CD25 as an immune regulatory molecule expressed on myeloid dendritic cells. Immunobiology. 213(9-10): 849-58.
Olejniczak K, et al. (2008) Biological properties of interleukin 2 and its role in pathogenesis of selected diseases--a review. Med Sci Monit. 14(10): RA179-89.
Chistiakov DA, et al. (2008) The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 118(1): 1-5.
Bien E, et al. (2008) Serum soluble interleukin 2 receptor alpha in human cancer of adults and children: a review. Biomarkers. 13(1): 1-26.