Anti-CD25 Antibody

Cat: 10165-RP02
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Anti-CD25 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD25 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD25
Immunogen
Recombinant Human IL2Ra protein (Catalog#10165-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL2Ra / CD25 (rh IL2Ra; Catalog#10165-H08H; NP_000408.1; Met 1-Cys 213). IL2Ra specific IgG was purified by human IL2Ra affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD25 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD25 Antibody Alternative Names
Anti-CD25 Antibody;Anti-IDDM10 Antibody;Anti-IL-2RA Antibody;Anti-IL2R Antibody;Anti-p55 Antibody;Anti-TCGFR Antibody
CD25 Background Information

CD25 (alpha-chain of IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development is associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of sIL-2Ralpha. In most haematological malignancies, including different types of leukaemias and lymphomas, sIL-2Ralpha has been found to be released directly from the surface of neoplastic cells thus reflecting the tumour bulk, turnover and activity. Several studies have proved that not only lymphoid cancer cells, but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, oesophagus and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 2 receptor, alpha
References
  • Driesen J, et al. (2008) CD25 as an immune regulatory molecule expressed on myeloid dendritic cells. Immunobiology. 213(9-10): 849-58.
  • Olejniczak K, et al. (2008) Biological properties of interleukin 2 and its role in pathogenesis of selected diseases--a review. Med Sci Monit. 14(10): RA179-89.
  • Chistiakov DA, et al. (2008) The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 118(1): 1-5.
  • Bien E, et al. (2008) Serum soluble interleukin 2 receptor alpha in human cancer of adults and children: a review. Biomarkers. 13(1): 1-26.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-CD25 Antibody Mouse Monoclonal ELISA 10165-MM14
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    Anti-CD25 Antibody (APC) Mouse Monoclonal FCM 10165-MM17-A
    Anti-CD25 Antibody (PE) Rabbit Monoclonal FCM 10165-R216-P
    Anti-CD25 Antibody (APC) Rabbit Monoclonal FCM 10165-R216-A
    Anti-CD25 Antibody Mouse Monoclonal FCM 10165-MM17
    Anti-CD25 Antibody Rabbit Monoclonal ELISA 10165-R702
    Anti-CD25 Antibody (PE) Mouse Monoclonal FCM 10165-MM17-P
    Anti-CD25 Antibody (PerCP) Rabbit Monoclonal FCM 10165-R216-C
    Anti-CD25 Antibody (PerCP) Mouse Monoclonal FCM 10165-MM17-C
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