All CD3 zeta reagents are produced in house and quality controlled, including 2 CD3 zeta Antibody, 39 CD3 zeta Gene, 1 CD3 zeta IPKit, 1 CD3 zeta Protein, 2 CD3 zeta qPCR. All CD3 zeta reagents are ready to use.
Recombinant CD3 zeta proteins are expressed by E. coli with fusion tags as N-GST.
CD3 zetaantibodies are validated with different applications, which are WB, ELISA, IP.
CD3 zetacDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD3 zeta of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.