CD24 Protein

Cluster of Differentiation 24

CD24 Products

CD24 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD24	Human	CD24/Fc Protein, Recombinant	11030-H02H

CD24 cDNA Clone

Molecule	Species	Description	Cat. No
CD24	Human	Homo sapiens CD24 cDNA Clone	HG11030-M
CD24	Rat	CD24 cDNA Clone / ORF Clone	RG80297-G

CD24 Related Areas

Cancer>>Cancer Biomarkers>>CD24

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD24

CD24 Alternative Names

CD24, CD24A, FLJ22950, FLJ43543, MGC75043 [Homo sapiens]

Cd24, Cd24a, HSA, Ly-52, nectadrin [Mus musculus]

CD24 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 24, also known as signal transducer CD24 or heat stable antigen CD24 (HSA), is a mucin-type glycosylphosphatidylinositol-linked glycoprotein expressed on the surface of B-cells, differentiating neuroblasts and many tumors. It is involved in molecular adhesion and metastatic tumor spread and serve as a normal receptor for P-selectin. The CD24 / P-selectin pathway could be important in dissimenating of tumor cells by facilitating the interaction with platelet and endothelial cells. It has also been considered as a tumor marker. High rate of CD24 expressions have been found in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer.

CD24 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Kristiansen G, et al. (2003) Tumour biological aspects of CD24, a mucin-like adhesion molecule. Journal of molecular histology. 35 (3): 255-62.