CD23 / FCER2 Protein & Antibody

Cluster of Differentiation 23 / Fc fragment of IgE, low affinity II, receptor for (CD23)

CD23 / FCER2 Products

CD23 / FCER2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD23/FCER2	Human	CD23/FCER2 Protein, Recombinant	10261-H07H
CD23/FCER2	Mouse	CD23/FCER2 Protein, Recombinant	50695-M07H

CD23 / FCER2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD23/FCER2	ELISA	CD23 / FCER2 Antibody	10261-MM05
Mouse CD23/FCER2	WB, ELISA	CD23 / FCER2 Antibody	50695-RP01
Mouse CD23/FCER2	WB, ELISA	CD23 / FCER2 Antibody (Antigen Affinity Purified)	50695-RP02

CD23 / FCER2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD23/FCER2	Human	Human CD23/FCER2 cDNA Clone / ORF Clone	HG10261-M
CD23/FCER2	Mouse	Mouse CD23/FCER2 cDNA Clone / ORF Clone	MG50695-G
CD23/FCER2	Rat	Rat CD23/FCER2 cDNA Clone / ORF Clone	RG80208-G

CD23 / FCER2 Related Areas

Immunology>>Adhesion Molecule>>Lectin>>CD23/FCER2

Immunology>>Fc Receptor>>CD23/FCER2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD23/FCER2

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Eosinophils>>CD23/FCER2

CD23 / FCER2 Alternative Names

CD23, FCER2, CD23A, CD23 a, CLEC4J, FCE2, IGEBF [Homo sapiens]

CD23, Fcer2, Fcer2a, Fce2, Ly-42 [Mus musculus]

CD23 / FCER2 Background

Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).

CD23 / FCER2 Related Studies

1. Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature. 358(6386): 505-7.
2. Punnonen J, et al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 90(8): 3730-4.
3. Yu P, et al. (1994) Negative feedback regulation of IgE synthesis by murine CD23. Nature. 369(6483): 753-6.