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CD23/FCER2 Protein, Antibody, ELISA Kit, cDNA Clone

CD23/FCER2 Related Areas

CD23/FCER2 Related Pathways

CD23/FCER2 Related Product

    CD23/FCER2 Summary & Protein Information

    CD23/FCER2 Background

    Gene Summary: The protein encoded by this FCER2 gene is a B-cell specific antigen, and a low-affinity receptor for IgE. CD23 has essential roles in B cell growth and differentiation, and the regulation of IgE production. CD23 also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
    General information above from NCBI
    Subunit structure: Homotrimer.
    Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.
    Post-translational: N- and O-glycosylated.
    The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
    Sequence similarity: Contains 1 C-type lectin domain.
    General information above from UniProt

    Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).

    CD23/FCER2 Alternative Name

    CD23/FCER2 Related Studies

  • Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature. 358(6386): 505-7.
  • Punnonen J, et al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 90(8): 3730-4.
  • Yu P, et al. (1994) Negative feedback regulation of IgE synthesis by murine CD23. Nature. 369(6483): 753-6.
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