Anti-CD23 Antibody

Cat: 50695-R011
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Anti-CD23 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD23 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD23
Immunogen
Recombinant Mouse CD23 / FCER2 protein (Catalog#50695-M07H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD23 / FCER2 (rM CD23 / FCER2; Catalog#50695-M07H; P20693-1; Glu51-Pro331).
Source
Monoclonal Rabbit IgG Clone #011
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD23 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD23 Antibody Alternative Names
Anti-CD23 Antibody;Anti-Fce2 Antibody;Anti-Fcer2 Antibody;Anti-Fcer2a Antibody;Anti-Ly-42 Antibody
CD23 Background Information

Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).

Full Name
Fc fragment of IgE receptor II
References
  • Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature. 358(6386): 505-7.
  • Punnonen J, et al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 90(8): 3730-4.
  • Yu P, et al. (1994) Negative feedback regulation of IgE synthesis by murine CD23. Nature. 369(6483): 753-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD23 Antibody Rabbit Polyclonal ELISA 50695-RP01
    Anti-CD23 Antibody (PerCP) Rabbit Monoclonal FCM 50695-R007-C
    Anti-CD23 Antibody (PE) Rabbit Monoclonal FCM 50695-R007-P
    Anti-CD23 Antibody (FITC) Rabbit Monoclonal FCM 50695-R007-F
    Anti-CD23 Antibody Rabbit Polyclonal ELISA 50695-RP02
    Anti-CD23 Antibody (APC) Rabbit Monoclonal FCM 50695-R007-A
    Anti-CD23 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50695-R007
    Anti-CD23 Antibody Rabbit Polyclonal WB,ELISA 10261-T48
    Anti-CD23 Antibody (FITC) Mouse Monoclonal FCM 10261-MM12-F
    Anti-CD23 Antibody (APC) Mouse Monoclonal FCM 10261-MM12-A
    Anti-CD23 Antibody (PE) Mouse Monoclonal FCM 10261-MM12-P
    Anti-CD23 Antibody (APC) Mouse Monoclonal FCM 10261-MM20-A
    Anti-CD23 Antibody (PE) Mouse Monoclonal FCM 10261-MM20-P
    Anti-CD23 Antibody Rabbit Monoclonal IHC-P 10261-R160
    Anti-CD23 Antibody (PerCP) Mouse Monoclonal FCM 10261-MM20-C
    Anti-CD23 Antibody (FITC) Mouse Monoclonal FCM 10261-MM20-F
    Anti-CD23 Antibody Rabbit Monoclonal ELISA 10261-R176
    Anti-CD23 Antibody Mouse Monoclonal FCM 10261-MM20
    Anti-CD23 Antibody Mouse Monoclonal IHC-P 10261-MM19
    Anti-CD23 Antibody Rabbit Polyclonal ELISA 10261-RP01
    Anti-CD23 Antibody (PerCP) Mouse Monoclonal FCM 10261-MM12-C
    Anti-CD23 Antibody Mouse Monoclonal ELISA,IHC-P 10261-MM05
    Anti-CD23 Antibody Mouse Monoclonal FCM 10261-MM12
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