CD226 Protein & Antibody (DNAM-1)

Cluster of Differentiation 226 (DNAX Accessory Molecule-1)

CD226 Products

CD226 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD226/DNAM-1	Human	CD226/DNAM-1/Fc Protein, Recombinant	10565-H03H
CD226/DNAM-1	Human	CD226/DNAM-1 Protein, Recombinant	10565-H08H
CD226/DNAM-1	Mouse	CD226/DNAM-1/Fc Protein, Recombinant	50232-M03H
CD226/DNAM-1	Mouse	CD226/DNAM-1 Protein, Recombinant	50232-M08H

  10565-H03H:

1. Immobilized CD112-his at 20 µg/ml (100 µl/well) can bind biotinylated DNAM1 with a linear range of 0.078-2.5 µg/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized CD112-Fc at 20 µg/ml (100 µl/well) can bind biotinylated DNAM1 with a linear range of 0.078-5 µg/ml. Measured by its binding ability in a functional ELISA.

3. Immobilized human CD155 at 20 µg/ml (100 µl/well) can bind human DNAM1 Fc chimera with a linear ranger of 1.28-160 ng/ml. Measured by its binding ability in a functional ELISA.

  10565-H08H: Immobilized human CD226 at 2 µg/ml (100 µl/well) can bind human CD112 with a linear ranger of 6.4-800 ng/ml. Measured by its binding ability in a functional ELISA.

  50232-M03H:  Immobilized recombinant mouse CD155/PVR at 1 µg/ml (100 µl/well) can bind recombinant mouse CD226/DNAM-1 with a linear range of 0.78-100 ng/ml.Measured by its ability to bind recombinant mouse CD155/PVR.

  50232-M08H: Immobilized mouse DNAM1 at 2 μg/ml ( 100 μl/well ) can bind mouse CD155 with a linear ranger of 6.4 - 160 ng/ml . Measured by its binding ability in a functional ELISA.

CD226 Antibody

Molecule	Application	Description	Cat. No
Human CD226/DNAM-1	WB, ELISA	CD226/DNAM-1 Antibody, Rabbit MAb	10565-R102
Human CD226/DNAM-1	WB, ELISA	Rabbit Polyclonal Antibody	10565-RP01
Human CD226/DNAM-1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10565-RP02
Mouse CD226/DNAM-1	WB, ELISA	Rabbit Monoclonal Antibody	50232-R026
Mouse CD226/DNAM-1	WB, ELISA	Rabbit Polyclonal Antibody	50232-RP01
Mouse CD226/DNAM-1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50232-RP02

CD226 cDNA Clone

Molecule	Species	Description	Cat. No
CD226/DNAM-1	Human	Homo sapiens CD226/DNAM-1 cDNA Clone(NM_006566.2)	HG10565-M
CD226/DNAM-1	Mouse	Mus musculus CD226/DNAM-1 cDNA Clone	MG50232-M
CD226/DNAM-1	Rat	DNAM-1 / CD226 cDNA Clone / ORF Clone	RG80369-G

CD226 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD226/DNAM-1

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD226/DNAM-1

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD226/DNAM-1

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD226/DNAM-1

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD226/DNAM-1

CD226 Alternative Names

CD226, DNAM-1, DNAM1, PTA1, TLiSA1 [Homo sapiens]

Cd226, DNAM-1, DNAM1, BC051526, Pta1, TLiSA1 [Mus musculus]

CD226 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226, also known as PTA1 or DNAM-1, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells, platelets, monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands.

CD226 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.