CD22 (Protein|Antibody|cDNA Clone|ELISA Kit)

All CD22 reagents are produced in house and quality controlled, including 21 CD22 Antibody, 5 CD22 Gene, 1 CD22 IPKit, 11 CD22 Lysate, 11 CD22 Protein, 1 CD22 qPCR. All CD22 reagents are ready to use.

Recombinant CD22 proteins are expressed by HEK293 Cells, HEK293 with fusion tags as C-His, C-human IgG1-Fc, Native.

CD22antibodies are validated with different applications, which are WB, IP, FCM, ELISA, IHC-P, ICC/IF, IF.

CD22cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD22 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

CD22 Protein (11)

Species

CD22 Protein, Human, Recombinant (aa 176-687, His Tag)

11958-H08H1

Expression host: HEK293 Cells

Human CD22/Siglec-2 Protein 9903

CD22 Protein, Human, Recombinant (ECD)

11958-HNAH

Expression host: HEK293

Human CD22 Protein 19510

CD22 Protein, Mouse, Recombinant (Fc Tag)

51177-M02H

Expression host: HEK293 Cells

Mouse CD22/Siglec-2 Protein 12154

CD22 Protein, Rat, Recombinant (ECD, His Tag)

81343-R08H

Expression host: HEK293 Cells

Rat CD22/Siglec-2 Protein 12701

CD22 Protein, Mouse, Recombinant (His Tag)

51177-M08H

Expression host: HEK293 Cells

Mouse CD22/Siglec-2 Protein 12155

CD22 Protein, Rat, Recombinant (ECD, Fc Tag)

81343-R02H

Expression host: HEK293 Cells

Rat CD22/Siglec-2 Protein 12700

CD22 Protein, Human, Recombinant (ECD, Fc Tag)

11958-H02H

Expression host: HEK293 Cells

Human CD22/Siglec-2 Protein 9901

CD22 Protein, Rhesus, Recombinant (His Tag)

90246-C08H

Expression host: HEK293 Cells

Rhesus CD22/Siglec-2 Protein 12908

CD22 Protein, Human, Recombinant (His Tag)

11958-H08H

Expression host: HEK293 Cells

Human CD22/Siglec-2 Protein 9902

CD22 Protein, Rhesus, Recombinant (Fc Tag)

90246-C02H

Expression host: HEK293 Cells

Rhesus CD22/Siglec-2 Protein 12907
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CD22 Antibody (21)

Application Clonality
Host

Anti-CD22 Antibody

81343-R072

Application: ELISA

Clonality: MAb

Anti-CD22 Antibody

11958-MM13

Application: FCM

Clonality: MAb

Human CD22/Siglec-2 Flow Cytometry (FC) 5284

Anti-CD22 Antibody

51177-R026

Application: FCM

Clonality: MAb

Mouse CD22/Siglec-2 Flow Cytometry (FC) 4973

Anti-CD22 Antibody (PE)

51177-R026-P

Application: FCM

Clonality: MAb

Mouse CD22/Siglec-2 Flow Cytometry (FC) 4971

Anti-CD22 Antibody

11958-R340

Application: ELISA,IHC-P,ICC/IF,IF

Clonality: MAb

Human CD22/Siglec-2 Immunofluorescence(IF) 14801

Anti-CD22 Antibody

11958-RP01

Application: ELISA

Clonality: PAb

Anti-CD22 Antibody

11958-MM07

Application: ELISA

Clonality: MAb

Anti-CD22 Antibody

51177-R087

Application: WB,IP

Clonality: MAb

Mouse CD22/Siglec-2 Western blot (WB) 4146

Anti-CD22 Antibody

81343-RP01

Application: ELISA

Clonality: PAb

Anti-CD22 Antibody (PerCP)

11958-MM13-C

Application: FCM

Clonality: MAb

Human CD22/Siglec-2 Flow Cytometry (FC) 17196

Anti-CD22 Antibody (PE)

11958-MM13-P

Application: FCM

Clonality: MAb

Human CD22/Siglec-2 Flow Cytometry (FC) 15075

Anti-CD22 Antibody

11958-MM12

Application: ELISA,IHC-P

Clonality: MAb

Human CD22/Siglec-2 Immunohistochemistry(IHC) 4538

Anti-CD22 Antibody (FITC)

11958-MM13-F

Application: FCM

Clonality: MAb

Human CD22/Siglec-2 Flow Cytometry (FC) 5285

Anti-CD22 Antibody

81343-T24

Application: ELISA,IHC-P

Clonality: PAb

Rat CD22/Siglec-2 Immunohistochemistry(IHC) 3138

Anti-CD22 Antibody

11958-T26

Application: ELISA,IHC-P,ICC/IF,IF

Clonality: PAb

Human CD22/Siglec-2 Immunohistochemistry(IHC) 15693

Anti-CD22 Antibody

51177-R060

Application: FCM

Clonality: MAb

Mouse CD22/Siglec-2 Flow Cytometry (FC) 4970

Anti-CD22 Antibody (APC)

51177-R060-A

Application: FCM

Clonality: MAb

Mouse CD22/Siglec-2 Flow Cytometry (FC) 15360

Anti-CD22 Antibody (FITC)

51177-R060-F

Application: FCM

Clonality: MAb

Mouse CD22/Siglec-2 Flow Cytometry (FC) 4972

Anti-CD22 Antibody (PE)

51177-R060-P

Application: FCM

Clonality: MAb

Mouse CD22/Siglec-2 Flow Cytometry (FC) 4972

Anti-CD22 Antibody

51177-R064

Application: ELISA

Clonality: MAb

Anti-CD22 Antibody

51177-R078

Application: WB

Clonality: MAb

Mouse CD22/Siglec-2 Western blot (WB) 4214
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CD22 cDNA Clone (5)

Rat
Human
NM_001107503.1
BC109306

CD22 qPCR Primer (1)

CD22 IP Kit (1)

CD22 Lysate (11)

CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.

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