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CD21  Antibody

All CD21 Reagents

Reactivity: Human  
Application: ELISA  
10811-RP01-400
10811-RP01-200
10811-RP01-100
400 µg 
200 µg 
100 µg 
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    Reactivity: Human  
    Application: ELISA  
    10811-MM11-50
    10811-MM11-200
    10811-MM11-100
    10811-MM11-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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      Reactivity: Human  
      Application: 
      10811-R257-P-25
      10811-R257-P-100
      25 Test 
      100 Tests 
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      Reactivity: Human  
      Application: FCM  
      10811-MM02-F-25
      10811-MM02-F-100
      25 Test 
      100 Tests 
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      Reactivity: Human  
      Application: ELISA  WB  IHC-P  IP  
      10811-RP02-50
      10811-RP02-200
      10811-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      Reactivity: Human  
      Application: 
      10811-MM02-A-25
      10811-MM02-A-100
      25 Test 
      100 Tests 
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      • Slide 1
      Reactivity: Human  
      Application: 
      10811-R019-50
      10811-R019-100
      10811-R019-1
      50 µg 
      100 µg 
      1 mg 
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        Reactivity: Human  
        Application: ELISA  FCM  
        10811-MM02-50
        10811-MM02-200
        10811-MM02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        • Slide 1
        Reactivity: Human  
        Application: 
        10811-R257-F-25
        10811-R257-F-100
        25 Test 
        100 Tests 
        Add to Cart
        • Slide 1
        Reactivity: Human  
        Application: ELISA  
        10811-R001-50
        10811-R001-100
        10811-R001-1
        50 µg 
        100 µg 
        1 mg 
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          Reactivity: Human  
          Application: ELISA  IHC-P  
          10811-R005-50
          10811-R005-100
          50 µg 
          100 µg 
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          • Slide 1
          Reactivity: Human  
          Application: 
          10811-R257-50
          10811-R257-100
          50 µg 
          100 µg 
          Add to Cart
          • Slide 1
          Reactivity: Human  
          Application: FCM  
          10811-MM02-P-25
          10811-MM02-P-100
          25 Test 
          100 Tests 
          Add to Cart
          • Slide 1
          Reactivity: Human  
          Application: 
          10811-R257-A-25
          10811-R257-A-100
          25 Test 
          100 Tests 
          Add to Cart
          • Slide 1

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          CD21 Related Area

          CD21 Related Pathways

          CD21 Summary & Protein Information

          CD21 Background

          Gene Summary: This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene
          General information above from NCBI
          Subunit structure: Interacts (via Sushi domain 1 and 2) with C3dg. {ECO:0000269|PubMed:11387479, ECO:0000269|PubMed:21527715}.
          Subcellular location: Membrane; Single-pass type I membrane protein.
          Tissue specificity: Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
          Involvement in disease: DISEASE: Systemic lupus erythematosus 9 (SLEB9) [MIM:610927]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:17360460}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Immunodeficiency, common variable, 7 (CVID7) [MIM:614699]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:22035880}. Note=The disease is caused by mutations affecting the gene represented in this entry.
          Sequence similarity: Belongs to the receptors of complement activation (RCA) family. {ECO:0000305}.; Contains 15 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
          General information above from UniProt

          The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD21, also known as Complement component (3d / Epstein Barr virus) receptor 2 and CR2, is a member of the CD system and is a protein involved in complement system. CD21 is present on all mature B-cells and some T-cells and follicular dendritic cells. CD21 on mature B-cells form a complex called the B cell receptor complex with two other membrane proteins, CD19 and CD81. CD21 has a function in the complement system through serving as the cellular receper specific for ligands such as C3 and C4 which can be attached to foreign macromolecules in order to remove or uptake them. This results in B-cells having enhanced response to the antigen.

          CD21 Alternative Name

          CD21 Related Studies

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
        • Joseph M, et al. (1989) Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21). Advanced in immunology. 46: 183-219.
        • Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature 358: 505 - 7.
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