CD21 Protein & Antibody

Cluster of Differentiation 21

CD21 Products

CD21 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD21	Human	CD21 Protein, Recombinant	10811-H08H

  10811-H08H: Immobilized human CD21 at 2 µg/ml (100 µl/well) can bind biotinylated human CD9. The EC₅₀ of biotinylated human CD9 is 1.76 µg/ml. Measured by its binding ability in a functional ELISA.

CD21 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD21	WB, ELISA	CD21 Antibody	10811-MM11
Human CD21	WB, ELISA	CD21 Antibody	10811-RP01
Human CD21	WB, ELISA, IHC-P	CD21 Antibody (Antigen Affinity Purified)	10811-RP02
Human CD21	WB, ELISA	CD21 Antibody	10811-R005

CD21 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD21	ELISA	CD21 ELISA Kit	SEK10811
Human CD21	ELISA	CD21 ELISA Pair Set, Human ELISA Pair Set	SEKA10811

CD21 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD21	Human	Homo sapiens CD21 cDNA Clone	HG10811-M

CD21 Related Areas

Immunology>>Innate Immunity>>Complement System>>CD21

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD21

CD21 Alternative Names

CD21, CR2, C3DR, RP11-78B10.1, SLEB9 [Homo sapiens]

CD21, Cr2, C3DR, CD35, Cr-1, Cr-2, Cr1, MGC130295 [Mus musculus]

CD21 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD21, also known as Complement component (3d / Epstein Barr virus) receptor 2 and CR2, is a member of the CD system and is a protein involved in complement system. CD21 is present on all mature B-cells and some T-cells and follicular dendritic cells. CD21 on mature B-cells form a complex called the B cell receptor complex with two other membrane proteins, CD19 and CD81. CD21 has a function in the complement system through serving as the cellular receper specific for ligands such as C3 and C4 which can be attached to foreign macromolecules in order to remove or uptake them. This results in B-cells having enhanced response to the antigen.

CD21 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Joseph M, et al. (1989) Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21). Advanced in immunology. 46: 183-219.
5. Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature 358: 505 – 7.