CD208 Protein & Antibody (DC-LAMP)

Cluster of Differentiation 208 (Dendritic Cell-Lysosomal Associated Membrane Protein)

CD208 Products

CD208 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD208/DC-LAMP	Human	CD208/DC-LAMP Protein, Recombinant	10527-H08H

CD208 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD208/DC-LAMP	WB, ELISA	CD208/DC-LAMP Antibody, Mouse Mab	10527-MM02
Human CD208/DC-LAMP	WB, ELISA	Rabbit Monoclonal Antibody	10527-R002
Human CD208/DC-LAMP	WB, ELISA	Rabbit Polyclonal Antibody	10527-RP01
Human CD208/DC-LAMP	WB, ELISA, IHC	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10527-RP02

CD208 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD208/DC-LAMP	Human	Homo sapiens CD208/DC-LAMP/LAMP3 cDNA Clone(NM_014398.3)	HG10527-M
CD208/DC-LAMP	Mouse	Mouse CD208/DC-LAMP/LAMP3 cDNA Clone / ORF Clone	MG50785-G
CD208/DC-LAMP	Cynomolgus	Cynomolgus monkey LAMP3 Gene cDNA Clone / ORF Clone	CG90247-G

CD208 Related Areas

Cancer>>Cancer Biomarkers>>CD208/DC-LAMP

Immunology>>Innate Immunity>>Lysosomal Enzyme>>CD208/DC-LAMP

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Other>>CD208/DC-LAMP

CD208 Alternative Names

CD208, DC-LAMP, DCLAMP, LAMP3, LAMP, TSC403 [Homo sapiens]

Cd208, DC-LAMP, DCLAMP, Lamp3, LAMP, 1200002D17Rik, TSC403 [Mus musculus]

CD208 Background

Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

CD208 Related Studies

1. Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
2. Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
3. Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.