Anti-LAMP3 Antibody

Cat: 10527-MM02
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Anti-LAMP3 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-LAMP3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human LAMP3
No cross-reactivity with Human LAMP1 / CD107a in ELISA
Immunogen
Recombinant Human LAMP3 protein (Catalog#10527-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD208 / LAMP3 (rh LAMP3; Catalog#10527-H08H; NP_055213.2; Lys 28-Thr 381). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #5F1G10F2
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LAMP3 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LAMP3 Antibody Alternative Names
Anti-CD208 Antibody;Anti-DC LAMP Antibody;Anti-DC-LAMP Antibody;Anti-DCLAMP Antibody;Anti-LAMP Antibody;Anti-LAMP-3 Antibody;Anti-TSC403 Antibody
LAMP3 Background Information

Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

Full Name
lysosomal associated membrane protein 3
References
  • Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
  • Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
  • Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LAMP3 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10527-T60
    Anti-LAMP3 Antibody Rabbit Polyclonal ELISA 10527-RP01
    Anti-LAMP3 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10527-R002
    Anti-LAMP3 Antibody Rabbit Monoclonal ELISA(Cap) 10527-R020
    Anti-LAMP3 Antibody Rabbit Polyclonal ELISA 10527-T16
    Anti-LAMP3 Antibody Rabbit Monoclonal ICC/IF,IF 10527-R007
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