Anti-CD200R1L Antibody

Cat: 11576-RP01
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Anti-CD200R1L Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD200R1L Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Cynomolgus
Specificity
Cynomolgus CD200R1L
Immunogen
Recombinant Cynomolgus CD200RLa protein (Catalog#11576-C08H)
Preparation
Produced in rabbits immunized with purified, recombinant Cynomolgus CD200RLa (rC CD200RLa; Catalog#11576-C08H; Met 1-Leu 240). Total IgG was purified by Protein A affinity chromatography
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD200R1L Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD200R1L Antibody Alternative Names
Anti-CD200RLa Antibody
CD200R1L Background Information

Cell surface glycoprotein CD200 receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L and CD200R2, is a single-pass type I  membrane protein which belongs to the CD200R family. CD200R1L / CD200R2. It contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. CD200 is a transmembrane protein delivering immunoregulatory signals after engagement of CD200R. A family of CD200Rs exist ( CD200R1, CD200R2, CD200R3, CD200R4 ) with different tissue expression and functional activity. In the presence of anti-CD200R2 / CD200R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD200 and one of its receptors, CD200R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3(+) regulatory T cells. Unlike anti-CD200R1, anti-CD200R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.

Full Name
CD200 receptor 1 like
References
  • Wright G.J., et al.,(2003), Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171:3034-3046.
  • Gorczynski R.M., et al., (2004), Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.Am. J. Reprod. Immunol. 52:147-163.
  • Muzny D.M., et al.,(2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD200R1L Antibody Mouse Monoclonal ELISA 11576-MM07
    Anti-CD200R1L Antibody Rabbit Monoclonal ELISA 11576-R015
    Anti-CD200R1L Antibody Rabbit Polyclonal ELISA 11576-RP02
    Anti-CD200R1L Antibody Mouse Monoclonal ELISA,ELISA(Det) 11620-MM09
    Anti-CD200R1L Antibody Rabbit Polyclonal ELISA 11620-RP01
    Anti-CD200R1L Antibody Rabbit Polyclonal ELISA 11620-RP02
    Anti-CD200R1L Antibody Rabbit Monoclonal ELISA 11620-R111
    Anti-CD200R1L Antibody Rabbit Monoclonal ELISA(Cap) 11620-R208
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