CD200 Protein & Antibody

Cluster of Differentiation 200

CD200 Products

CD200 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD200	Human	CD200/Fc Protein, Recombinant	10886-H03H
CD200	Human	CD200 Protein, Recombinant	10886-H08H
CD200	Mouse	CD200 Protein, Recombinant	50074-M08H

  10886-H03H: Immobilized human CD200R1 at 1 µg/ml (100 µl/well) can bind human CD200 Fc Chimera with a linear range of 0.12-16 ng/ml. Measured by its binding ability in a functional ELISA.

  10886-H08H: Immobilized recombinant human CD200 at 1 µg/ml (100 µl/well) can bind human CD200R1/Fc Chimera with a linear range of 0.12-16 ng/ml. Measured by its binding ability in a functional ELISA.

  50074-M08H: Immobilized recombinant mouse CD200 at 1 µg/ml (100 µl/well) can bind mouse CD200R1/Fc with a linear range of 1.5-200 ng/ml. Measured by its binding ability in a functional ELISA.

CD200 Antibody

Molecule	Application	Description	Cat. No
Human CD200	WB, ELISA	Mouse Monoclonal Antibody	10886-MM03
Human CD200	WB, ELISA	Rabbit Monoclonal Antibody	10886-R005
Human CD200	WB, ELISA	Rabbit Polyclonal Antibody	10886-RP01
Mouse CD200	WB, ELISA	Rabbit Polyclonal Antibody	50074-RP01
Mouse CD200	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50074-RP02
Mouse CD200	WB, FCM	CD200 Antibody	50074-R002

CD200 ELISA Kit

Molecule	Application	Description	Cat. No
Human CD200	ELISA	CD200 ELISA Kit	SEK10886

CD200 cDNA Clone

Molecule	Species	Description	Cat. No
CD200	Human	Homo sapiens CD200 cDNA Clone(NM_005944.5)	HG10886-M
CD200	Mouse	Mus musculus CD200 cDNA Clone	MG50074-M

CD200 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD200

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD200

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD200

CD200 Alternative Names

CD200, MOX1, MOX2, MRC, OX-2 [Homo sapiens]

Cd200, Mox2, OX2 [Mus musculus]

CD200 Background

CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

CD200 Related Studies

1. Minas K, et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit Rev Immunol. 26(3): 213-30.
2. Wang XJ, et al. (2007) CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. J Neuroimmune Pharmacol. 2(3): 259-64.
3. Wong KK, et al. (2010) The role of CD200 in immunity to B cell lymphoma. J Leukoc Biol. 88(2): 361-72.