Quick Order

CD200 / OX-2 Antibody, Mouse MAb

    DatasheetReviewsRelated ProductsProtocols
    Human CD200 Antibody Product Information
    Immunogen:Recombinant Human CD200 protein (Catalog#10886-H08H)
    Clone ID:8E10B7
    Ig Type:Mouse IgG1
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD200 (rh CD200; Catalog#10886-H08H; NP_005935.4; Met 1-Gly 232). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other CD200 Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10886-MM17-P-25
    10886-MM17-P-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: IHC-P  
    • Slide 1
    • Slide 1
    10886-R333-50
    10886-R333-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: WB  
    • Slide 1
    10886-T32-50
    10886-T32-200
    10886-T32-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10886-R005-50
      10886-R005-100
      10886-R005-1
      50 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  
      • Slide 1
      10886-RP01-400
      10886-RP01-200
      10886-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  FCM  
      • Slide 1
      10886-MM17-50
      10886-MM17-200
      10886-MM17-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10886-T16-50
        10886-T16-200
        10886-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: FCM  
        • Slide 1
        • Slide 1
        50074-R002-P-25
        50074-R002-P-100
        25 Test 
        100 Tests 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50074-RP02-50
          50074-RP02-200
          50074-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: FCM  
          • Slide 1
          50074-R002-A-25
          50074-R002-A-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50074-RP01-400
            50074-RP01-200
            50074-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50074-R002-50
            50074-R002-100
            50 µg 
            100 µg 
            Add to Cart
            CD200/OX2 Background

            CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            Human CD200/OX2 References
          • Minas K, et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit Rev Immunol. 26(3): 213-30.
          • Wang XJ, et al. (2007) CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. J Neuroimmune Pharmacol. 2(3): 259-64.
          • Wong KK, et al. (2010) The role of CD200 in immunity to B cell lymphoma. J Leukoc Biol. 88(2): 361-72.
          • Product nameProduct name
            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"