Anti-CD200 Antibody (PE)

Cat: 50074-R002-P
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Anti-CD200 Antibody (PE) (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD200 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD200
Immunogen
Recombinant Mouse CD200 protein (Catalog#50074-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD200 (rM CD200; Catalog#50074-M08H; NP_001076017.1; Met1-Gly232) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #002
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
2 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD200 Antibody (PE) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD200 Antibody (PE) (Rabbit Monoclonal antibody) Images
Mouse CD200/OX2 Flow Cytometry (FC) 5549
Analysis of CD200 expression on spleen lymphocytes.
Anti-CD200 Antibody (PE) Alternative Names
Anti-Mox2 Antibody;Anti-OX2 Antibody
CD200 Background Information

CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
Cd200 molecule
References
  • Minas K, et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit Rev Immunol. 26(3): 213-30.
  • Wang XJ, et al. (2007) CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. J Neuroimmune Pharmacol. 2(3): 259-64.
  • Wong KK, et al. (2010) The role of CD200 in immunity to B cell lymphoma. J Leukoc Biol. 88(2): 361-72.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD200 Antibody Rabbit Monoclonal FCM 50074-R002
    Anti-CD200 Antibody (APC) Rabbit Monoclonal FCM 50074-R002-A
    Anti-CD200 Antibody Rabbit Polyclonal ELISA 50074-RP01
    Anti-CD200 Antibody Rabbit Polyclonal ELISA 50074-RP02
    Anti-CD200 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 10886-R005
    Anti-CD200 Antibody Rabbit Polyclonal WB,ELISA 10886-RP01
    Anti-CD200 Antibody Rabbit Polyclonal WB 10886-T32
    Anti-CD200 Antibody Rabbit Polyclonal ELISA 10886-T16
    Anti-CD200 Antibody Mouse Monoclonal ELISA 10886-MM03
    Anti-CD200 Antibody (PE) Mouse Monoclonal FCM 10886-MM17-P
    Anti-CD200 Antibody Rabbit Monoclonal IHC-P 10886-R333
    Anti-CD200 Antibody Mouse Monoclonal ELISA,FCM 10886-MM17
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