CD20 / MS4A1 Protein & Antibody

Cluster of Differentiation 20 / Membrane-spanning 4-domains, subfamily A, member 1

CD20 / MS4A1 Products

CD20 / MS4A1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD20/MS4A1	Human	CD20 / MS4A1 (aa 213-297) Protein, Recombinant	11007-H07H2
CD20/MS4A1	Ferret	CD20/MS4A1 Protein, Recombinant	60004-F08H

CD20 / MS4A1 Antibody

Molecule	Application	Description	Cat. No
Human CD20/MS4A1	FCM	CD20 / MS4A1 Antibody ( FITC )	11007-R001-F
Ferret CD20/MS4A1	WB, ELISA	CD20 / MS4A1 Antibody (Antigen Affinity Purified)	60004-RP02

CD20 / MS4A1 cDNA Clone

Molecule	Species	Description	Cat. No
CD20/MS4A1	Human	CD20/MS4A1 cDNA Clone / ORF Clone	HG11007-M
CD20/MS4A1	Mouse	CD20/MS4A1 cDNA Clone / ORF Clone	MG50399-G
CD20/MS4A1	Ferret	CD20 / MS4A1 cDNA Clone / ORF Clone	FG60004-G
CD20/MS4A1	Cynomolgus	MS4A1 cDNA Clone / ORF Clone	CG90052-G

CD20 / MS4A1 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD20/MS4A1

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>CD20/MS4A1

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD20/MS4A1

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD20/MS4A1

CD20 / MS4A1 Alternative Names

CD20, MS4A1, B1, Bp35, CVID5, LEU-16, MGC3969, MS4A2, S7 [Homo sapiens]

Cd20, Ms4a1, AA960661, Cd20, Ly-44, Ms4a2 [Mus musculus]

CD20 / MS4A1 Background

CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

CD20 / MS4A1 Related Studies

1. Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
2. Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
3. Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.