Anti-CD20 Antibody

Cat: 60004-RP02
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Anti-CD20 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD20 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Ferret
Specificity
Ferret CD20
Immunogen
Recombinant Ferret CD20 / MS4A1 protein (Catalog#60004-F08H)
Preparation
Produced in rabbits immunized with purified, recombinant Ferret CD20 / MS4A1 (rF CD20 / MS4A1; Catalog#60004-F08H; Glu 213-Pro 297). CD20 / MS4A1 specific IgG was purified by Ferret CD20 / MS4A1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD20 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:5000-1:20000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD20 Antibody (Rabbit Polyclonal antibody) Images
Ferret CD20/MS4A1  Immunohistochemistry(IHC) 4777
Immunochemical staining of ferret CD20 in ferret spleen with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Ferret CD20/MS4A1  Immunohistochemistry(IHC) 4778
Immunochemical staining of ferret CD20 in ferret colon with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
CD20 Background Information

CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
membrane-spanning 4-domains, subfamily A, member 1
References
  • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
  • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
  • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.
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    Anti-CD20 Antibody (APC) Rabbit Monoclonal FCM 11007-R001-A
    Anti-CD20 Antibody Rabbit Polyclonal ELISA 11007-RP01
    Anti-CD20 Antibody Mouse Monoclonal ELISA 11007-MM01
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